Serial Bronchoalveolar Lavage Fluid Aspergillus Galactomannan and Treatment Response in Invasive Pulmonary Aspergillosis

被引：2

作者：

Friedman, Daniel Z. P. ^{[1
,2
,7
]}

Theel, Elitza S. ^{[3
]}

Walker, Randall C. ^{[1
]}

Vikram, Holenarasipur R. ^{[4
]}

Razonable, Raymund R. ^{[1
,5
]}

Vergidis, Paschalis ^{[1
,5
,6
]}

机构：

[1] Mayo Clin, Sect Infect Dis, Dept Med, Rochester, MN USA

[2] Univ Chicago, Sect Infect Dis & Publ Hlth, Chicago, IL USA

[3] Mayo Clin, Dept Lab Med & Pathol, Div Clin Microbiol, Rochester, MN USA

[4] Mayo Clin, Div Infect Dis, Phoenix, AZ USA

[5] Mayo Clin, William J von Liebig Ctr Transplantat & Clin Regen, Rochester, MN USA

[6] Mayo Clin, 200 First St SW, Rochester, MN 55905 USA

[7] Univ Chicago, 5841 S Maryland Ave, Chicago, IL 60637 USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2024年 / 11卷 / 04期

关键词：

aspergillosis; bronchoscopy; galactomannan; hematopoietic stem cell transplant; solid organ transplant; DIAGNOSIS;

D O I：

10.1093/ofid/ofae114

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied patients diagnosed with aspergillosis based on positive bronchoalveolar lavage (BAL) Aspergillus galactomannan (GM) who had follow-up BAL sampling within 180 days. GM trend and clinical outcome were concordant in only 60% (30/50). While useful for the initial diagnosis, BAL GM trending does not always correlate with treatment response.

引用

页数：4

共 12 条

[1] Detection of Galactomannan in Bronchoalveolar Lavage Fluid Samples of Patients at Risk for Invasive Pulmonary Aspergillosis: Analytical and Clinical Validity [J].

D'Haese, Jorien ;

Theunissen, Koen ;

Vermeulen, Edith ;

Schoemans, Helene ;

De Vlieger, Greet ;

Lammertijn, Liesbet ;

Meersseman, Philippe ;

Meersseman, Wouter ;

Lagrou, Katrien ;

Maertens, Johan .

JOURNAL OF CLINICAL MICROBIOLOGY, 2012, 50 (04) :1258-1263

[2] Galactomannan detection in broncho-alveolar lavage fluid for invasive aspergillosis in immunocompromised patients [J].

de Heer, Koen ;

Gerritsen, Marije G. ;

Visser, Caroline E. ;

Leeflang, Mariska M. G. .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2019, (05)

[3] Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium [J].

Donnelly, J. Peter ;

Chen, Sharon C. ;

Kauffman, Carol A. ;

Steinbach, William J. ;

Baddley, John W. ;

Verweij, Paul E. ;

Clancy, Cornelius J. ;

Wingard, John R. ;

Lockhart, Shawn R. ;

Groll, Andreas H. ;

Sorrell, Tania C. ;

Bassetti, Matteo ;

Akan, Hamdi ;

Alexander, Barbara D. ;

Andes, David ;

Azoulay, Elie ;

Bialek, Ralf ;

Bradsher, Robert W., Jr. ;

Bretagne, Stephane ;

Calandra, Thierry ;

Caliendo, Angela M. ;

Castagnola, Elio ;

Cruciani, Mario ;

Cuenca-Estrella, Manuel ;

Decker, Catherine F. ;

Desai, Sujal R. ;

Fisher, Brian ;

Harrison, Thomas ;

Heussel, Claus Peter ;

Jensen, Henrik E. ;

Kibbler, Christopher C. ;

Kontoyiannis, Dimitrios P. ;

Kullberg, Bart-Jan ;

Lagrou, Katrien ;

Lamoth, Frederic ;

Lehrnbecher, Thomas ;

Loeffler, Jurgen ;

Lortholary, Olivier ;

Maertens, Johan ;

Marchetti, Oscar ;

Marr, Kieren A. ;

Masur, Henry ;

Meis, Jacques F. ;

Morrisey, C. Orla ;

Nucci, Marcio ;

Ostrosky-Zeichner, Luis ;

Pagano, Livio ;

Patterson, Thomas F. ;

Perfect, John R. ;

Racil, Zdenek .

CLINICAL INFECTIOUS DISEASES, 2020, 71 (06) :1367-1376

[4] Prognostic Features of Galactomannan Antigenemia in Galactomannan-Positive Invasive Aspergillosis [J].

Koo, Sophia ;

Bryar, Julie M. ;

Baden, Lindsey R. ;

Marty, Francisco M. .

JOURNAL OF CLINICAL MICROBIOLOGY, 2010, 48 (04) :1255-1260

[5] Galactomannan detection for invasive aspergillosis in immunocompromised patients [J].

Leeflang, Mariska M. G. ;

Debets-Ossenkopp, Yvette J. ;

Wang, Junfeng ;

Visser, Caroline E. ;

Scholten, Rob J. P. M. ;

Hooft, Lotty ;

Bijlmer, Henk A. ;

Reitsma, Johannes B. ;

Zhang, Mingming ;

Bossuyt, Patrick M. M. ;

Vandenbroucke-Grauls, Christina M. .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2015, (12)

[6] Detection of circulating galactomannan for the diagnosis and management of invasive aspergillosis [J].

Mennink-Kersten, MASH ;

Donnelly, JP ;

Verweij, PE .

LANCET INFECTIOUS DISEASES, 2004, 4 (06) :349-357

[7] Defining Galactomannan Positivity in the Updated EORTC/MSGERC Consensus Definitions of Invasive Fungal Diseases [J].

Mercier, Toine ;

Castagnola, Elio ;

Marr, Kieren A. ;

Wheat, L. Joseph ;

Verweij, Paul E. ;

Maertens, Johan A. .

CLINICAL INFECTIOUS DISEASES, 2021, 72 :S89-S94

[8] Correlation between Circulating Fungal Biomarkers and Clinical Outcome in Invasive Aspergillosis [J].

Neofytos, Dionysios ;

Railkar, Radha ;

Mullane, Kathleen M. ;

Fredricks, David N. ;

Granwehr, Bruno ;

Marr, Kieren A. ;

Almyroudis, Nikolaos G. ;

Kontoyiannis, Dimitrios P. ;

Maertens, Johan ;

Fox, Rebecca ;

Douglas, Cameron ;

Iannone, Robert ;

Kauh, Eunkyung ;

Shire, Norah .

PLOS ONE, 2015, 10 (06)

[9] Diagnosis of invasive aspergillosis using a galactomannan assay: A meta-analysis [J].

Pfeiffer, CD ;

Fine, JP ;

Safdar, N .

CLINICAL INFECTIOUS DISEASES, 2006, 42 (10) :1417-1427

[10]

Platelia Aspergillus Ag, 2013, Product Sheet

← 1 2 →