CD47 promotes peripheral T cell survival by preventing dendritic cell-mediated T cell necroptosis

被引：5

作者：

Komori, Satomi ^{[1
,2
]}

Saito, Yasuyuki ^{[2
]}

Nishimura, Taichi ^{[2
]}

Respatika, Datu ^{[2
,3
]}

Endoh, Hiromi ^{[4
]}

Yoshida, Hiroki ^{[2
]}

Sugihara, Risa ^{[2
]}

Iida-Norita, Rie ^{[2
]}

Afroj, Tania ^{[1
,2
]}

Takai, Tomoko ^{[1
,2
]}

Oduori, Okechi S. ^{[1
,2
]}

Nitta, Eriko ^{[4
]}

Kotani, Takenori ^{[2
]}

Murata, Yoji ^{[2
]}

Kaneko, Yoriaki ^{[5
]}

Nitta, Ryo ^{[4
]}

Ohnishi, Hiroshi ^{[6
]}

Matozaki, Takashi ^{[1
,2
]}

机构：

[1] Kobe Univ, Dept Biochem & Mol Biol, Div Biosignal Regulat, Grad Sch Med, Kobe, Hyogo 6500047, Japan

[2] Kobe Univ, Dept Biochem & Mol Biol, Divis Mol & Cellular Signaling, Grad Sch Med, Kobe, Hyogo 6500017, Japan

[3] Gadjah Mada Univ, Dept Ophthalmol, Div Reconstruct Oculoplasty & Oncol, Fac Med Publ Hlth & Nursing, Yogyakarta 55281, Indonesia

[4] Kobe Univ, Dept Physiol & Cell Biol, Div Struct Med & Anat, Grad Sch Med, Kobe, Hyogo 6500017, Japan

[5] Gunma Univ, Dept Nephrol & Rheumatol, Grad Sch Med, Gunma 3718511, Japan

[6] Gunma Univ, Dept Lab Sci, Grad Sch Hlth Sci, Gunma 3718514, Japan

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2023年 / 120卷 / 33期

基金：

日本学术振兴会; 日本科学技术振兴机构;

关键词：

T cell; dendritic cell; necroptosis; SIRP alpha; CD47; ALPHA SIRP-ALPHA; RED-BLOOD-CELLS; PHAGOCYTOSIS; INFLAMMATION; HOMEOSTASIS; EXPRESSION; CLEARANCE; ABLATION; RECEPTOR; KINASE;

D O I：

10.1073/pnas.2304943120

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Conventional dendritic cells (cDCs) are required for peripheral T cell homeostasis in lymphoid organs, but the molecular mechanism underlying this requirement has remained unclear. We here show that T cell-specific CD47-deficient (Cd47(Delta T)) mice have a markedly reduced number of T cells in peripheral tissues. Direct interaction of CD47-deficient T cells with cDCs resulted in activation of the latter cells, which in turn induced necroptosis of the former cells. The deficiency and cell death of T cells in Cd47(Delta T) mice required expression of its receptor signal regulatory protein alpha on cDCs. The development of CD4(+) T helper cell-dependent contact hypersensitivity and inhibition of tumor growth by cytotoxic CD8(+) T cells were both markedly impaired in Cd47(Delta T) mice. CD47 on T cells thus likely prevents their necroptotic cell death initiated by cDCs and thereby promotes T cell survival and function.

引用

页数：12

共 47 条

[1] Distinct Roles for Neutrophils and Dendritic Cells in Inflammation and Autoimmunity in motheaten Mice [J].