Lipid Peroxidation-Related Redox Signaling in Osteosarcoma

被引：2
|
作者：
Sunjic, Suzana Borovic [1 ]
Jaganjac, Morana [1 ]
Vlainic, Josipa [1 ]
Halasz, Mirna [1 ]
Zarkovic, Neven [1 ]
机构：
[1] Rudjer Boskovic Inst, Lab Oxidat Stress, Div Mol Med, Bijenicka 54, Zagreb 10000, Croatia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 08期
关键词：
lipid peroxidation; reactive aldehydes; redox signaling; osteosarcoma; SYNTHETASE GENE-EXPRESSION; ALDEHYDE DEHYDROGENASE 1A1; ACID-BINDING PROTEIN; IN-VITRO; INDOLEAMINE 2,3-DIOXYGENASE; MOLECULAR-MECHANISMS; OXYGEN AVAILABILITY; MITOCHONDRIAL ROS; ADAPTIVE RESPONSE; NRF2; EXPRESSION;
D O I：
10.3390/ijms25084559
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oxidative stress and lipid peroxidation play important roles in numerous physiological and pathological processes, while the bioactive products of lipid peroxidation, lipid hydroperoxides and reactive aldehydes, act as important mediators of redox signaling in normal and malignant cells. Many types of cancer, including osteosarcoma, express altered redox signaling pathways. Such redox signaling pathways protect cancer cells from the cytotoxic effects of oxidative stress, thus supporting malignant transformation, and eventually from cytotoxic anticancer therapies associated with oxidative stress. In this review, we aim to explore the status of lipid peroxidation in osteosarcoma and highlight the involvement of lipid peroxidation products in redox signaling pathways, including the involvement of lipid peroxidation in osteosarcoma therapies.
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页数：29
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