Gut-Brain Axis;
Gut Dysbiosis;
Gut Microbiome;
Mental Health;
Neurological Disorders;
TRYPTOPHAN-METABOLISM;
BRAIN;
DEPRESSION;
PATHWAYS;
LACTATE;
D O I:
10.1007/s40495-024-00357-z
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
Purpose of ReviewStarting from scratch to understand what a microbiome is and its significance in our daily lives has become a crucial subject of study. This review aims to delve into the impact of diet on the gut microbiota and how alterations in the gut microflora can contribute to dysbiosis, anxiety, depression, and other neurological disorders.Recent FindingsOver the past one decade, extensive research has been conducted to explore the role of the gut microbiome in mental health and its potential involvement in causing mental illnesses. Some studies have made hypotheses about how gut microbes can influence both psychological and neurological aspects. One primary area of investigation has been the impact of diet on shaping the composition of the gut microbiota and whether it can affect brain function or even play a role in the prevention or management of mental disorders such as depression, anxiety, schizophrenia, and Alzheimer's disease. These conditions and neurological diseases have garnered significant attention from the scientific community due to their growing burden on the field of medical science.SummaryWhile many studies on the gut-brain axis (GBA) have traditionally focused on aspects like satiety and digestive processes, it is important to recognize that the gut microbiota constitutes a complex and dynamic ecosystem that plays a vital role in the overall functioning of the human body. Consequently, it exerts a profound influence on an individual's health and their susceptibility to various illnesses.
机构:
Univ Michigan, Sch Med, Div Gastroenterol, Ann Arbor, MI USAUniv Michigan, Sch Med, Div Gastroenterol, Ann Arbor, MI USA
Shreiner, Andrew B.
Kao, John Y.
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机构:
Univ Michigan, Sch Med, Div Gastroenterol, Ann Arbor, MI USAUniv Michigan, Sch Med, Div Gastroenterol, Ann Arbor, MI USA
Kao, John Y.
Young, Vincent B.
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机构:
Univ Michigan, Sch Med, Dept Internal Med, Div Infect Dis,Dept Microbiol & Immunol, Ann Arbor, MI USAUniv Michigan, Sch Med, Div Gastroenterol, Ann Arbor, MI USA
机构:
Amer Univ Sharjah, Coll Arts & Sci, Univ City 26666, Sharjah, U Arab Emirates
Istinye Univ, Fac Med, Dept Med Biol, TR-34010 Istanbul, TurkeyAmer Univ Sharjah, Coll Arts & Sci, Univ City 26666, Sharjah, U Arab Emirates
Siddiqui, Ruqaiyyah
Makhlouf, Zinb
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机构:
Amer Univ Sharjah, Coll Arts & Sci, Univ City 26666, Sharjah, U Arab EmiratesAmer Univ Sharjah, Coll Arts & Sci, Univ City 26666, Sharjah, U Arab Emirates
Makhlouf, Zinb
Alharbi, Ahmad M. M.
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机构:
Taif Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Taif 21944, Saudi ArabiaAmer Univ Sharjah, Coll Arts & Sci, Univ City 26666, Sharjah, U Arab Emirates
Alharbi, Ahmad M. M.
Alfahemi, Hasan
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h-index: 0
机构:
Al Baha Univ, Fac Med, Dept Med Microbiol, Al Baha 65799, Saudi ArabiaAmer Univ Sharjah, Coll Arts & Sci, Univ City 26666, Sharjah, U Arab Emirates
Alfahemi, Hasan
Khan, Naveed Ahmed
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h-index: 0
机构:
Istinye Univ, Fac Med, Dept Med Biol, TR-34010 Istanbul, Turkey
Univ Sharjah, Coll Med, Dept Clin Sci, Univ City 27272, Sharjah, U Arab EmiratesAmer Univ Sharjah, Coll Arts & Sci, Univ City 26666, Sharjah, U Arab Emirates
机构:
Unitat Mixta d’Investigació en Genòmica i Salut, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)-Salud Pública/Institut Cavanilles de Biodiversitat i Biologia Evolutiva (Universitat de València), Ave
CIBER en Epidemiología y Salud Pública (CIBERESP), MadridUnitat Mixta d’Investigació en Genòmica i Salut, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)-Salud Pública/Institut Cavanilles de Biodiversitat i Biologia Evolutiva (Universitat de València), Ave
机构:
St Louis Univ, Dept Psychiat, Sch Med, Monteleone Hall,1438 S Grand Blvd, St Louis, MO 63104 USASt Louis Univ, Dept Psychiat, Sch Med, Monteleone Hall,1438 S Grand Blvd, St Louis, MO 63104 USA
Schrodt, Clare
Mahavni, Anika
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h-index: 0
机构:
St Louis Univ, Dept Psychiat, Sch Med, Monteleone Hall,1438 S Grand Blvd, St Louis, MO 63104 USASt Louis Univ, Dept Psychiat, Sch Med, Monteleone Hall,1438 S Grand Blvd, St Louis, MO 63104 USA
Mahavni, Anika
McNamara, Griffin P. J.
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h-index: 0
机构:
St Louis Univ, Dept Psychiat, Sch Med, Monteleone Hall,1438 S Grand Blvd, St Louis, MO 63104 USASt Louis Univ, Dept Psychiat, Sch Med, Monteleone Hall,1438 S Grand Blvd, St Louis, MO 63104 USA
McNamara, Griffin P. J.
Tallman, Morgan D.
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h-index: 0
机构:
St Louis Univ, Dept Psychiat, Sch Med, Monteleone Hall,1438 S Grand Blvd, St Louis, MO 63104 USASt Louis Univ, Dept Psychiat, Sch Med, Monteleone Hall,1438 S Grand Blvd, St Louis, MO 63104 USA
Tallman, Morgan D.
Bruger, Bryanna T.
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h-index: 0
机构:
St Louis Univ, Dept Psychiat, Sch Med, Monteleone Hall,1438 S Grand Blvd, St Louis, MO 63104 USASt Louis Univ, Dept Psychiat, Sch Med, Monteleone Hall,1438 S Grand Blvd, St Louis, MO 63104 USA
Bruger, Bryanna T.
Schwarz, Lauren
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h-index: 0
机构:
St Louis Univ, Dept Psychiat, Sch Med, Monteleone Hall,1438 S Grand Blvd, St Louis, MO 63104 USASt Louis Univ, Dept Psychiat, Sch Med, Monteleone Hall,1438 S Grand Blvd, St Louis, MO 63104 USA
Schwarz, Lauren
Bhattacharyya, Anjan
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机构:
Emory Univ, Dept Psychiat, Atlanta, GA 30322 USASt Louis Univ, Dept Psychiat, Sch Med, Monteleone Hall,1438 S Grand Blvd, St Louis, MO 63104 USA