The multifaceted role of autophagy in skin autoimmune disorders: a guardian or culprit?

被引：4
作者：
Lin, Yi [1 ]
Wu, Xiuyi [1 ]
Yang, Yiwen [1 ]
Wu, Yue [1 ]
Xiang, Leihong [1 ]
Zhang, Chengfeng [1 ]
机构：
[1] Fudan Univ, Huashan Hosp, Dept Dermatol, Shanghai, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
基金：
中国国家自然科学基金; 上海市自然科学基金;
关键词：
autophagy; skin autoimmune disorder; psoriasis; atopic dermatitis; vitiligo; systemic lupus erythematosus; alopecia areata; systemic sclerosis; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CELL-DEATH; MAMMALIAN AUTOPHAGY; EXPRESSION; SUSCEPTIBILITY; PATHOGENESIS; ASSOCIATION; MECHANISMS; PSORIASIS; MACHINERY;
D O I：
10.3389/fimmu.2024.1343987
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Autophagy is a cellular process that functions to maintain intracellular homeostasis via the degradation and recycling of defective organelles or damaged proteins. This dynamic mechanism participates in various biological processes, such as the regulation of cellular differentiation, proliferation, survival, and the modulation of inflammation and immune responses. Recent evidence has demonstrated the involvement of polymorphisms in autophagy-related genes in various skin autoimmune diseases. In addition, autophagy, along with autophagy-related proteins, also contributes to homeostasis maintenance and immune regulation in the skin, which is associated with skin autoimmune disorders. This review aims to provide an overview of the multifaceted role of autophagy in skin autoimmune diseases and shed light on the potential of autophagy-targeting therapeutic strategies in dermatology.
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页数：13
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