Lipoprotein(a): association with atherosclerotic and valvular disease and emerging therapies

被引：0

作者：

Abrignani, Maurizio Giuseppe ^{[1
]}

Maloberti, Alessandro ^{[2
,3
]}

Di Fusco, Stefania Angela ^{[4
]}

Luca, Fabiana ^{[5
]}

Cesaro, Arturo ^{[6
,7
]}

Acerbo, Vincenzo ^{[6
]}

Fabbri, Saverio ^{[3
]}

di Matteo, Irene ^{[8
]}

Amico, Antonio F. ^{[9
]}

Temporelli, Pier Luigi ^{[10
]}

Riccio, Carmine ^{[11
]}

Colivicchi, Furio ^{[4
]}

Grimaldi, Massimo ^{[12
]}

Gabrielli, Domenico ^{[13
,14
]}

Oliva, Fabrizio ^{[8
,15
]}

机构：

[1] ASP Trapani, POP Borsellino, UOC Cardiol, Marsala, Italy

[2] ASST Grande Osped Metropolitano Niguarda, Riabilitaz Cardiol, Cardiol 4, Milan, Italy

[3] Univ Milano Bicocca, Dipartimento Med & Chirurg, Milan, Italy

[4] Presidio Osped San Filippo Neri ASL Roma 1, UOC Cardiol Clin & Riabilitat, Rome, Italy

[5] Grande Osped Metropolitano Bianchi Melacrino More, UTIC, Cardiol Interventist, Reggio Di Calabria, Italy

[6] Univ Campania L Vanvitelli, Naples, Italy

[7] AORN S Anna & Sebastiano, Div Cardiol, Caserta, Italy

[8] Grande Osped Metropolitano Niguarda, UOC Cardiol Emodinam 1, Milan, Italy

[9] Osped San Giuseppe Copertino, UO Cardiol, Copertino, LE, Italy

[10] IRCCS Gattico Veruno NO, ICS Maugeri, Div Cardiol Riabilitat, Gattico Veruno, NO, Italy

[11] AORN St Anna & San Sebastiano, Dipartimento Cardiovasc, UOSD Follow Up Paziente Postacuto, Caserta, Italy

[12] Osped Miulli Acquaviva Fonti, UOC Cardiol, Bari, Italy

[13] Azienda Osped San Camillo Forlanini, UOC Cardiol UTIC, Rome, Italy

[14] Heart Care Fdn, Fdn Tuo Cuore, Florence, Italy

[15] Assoc Nazl Med Cardiol Osped ANMCO, Florence, Italy

来源：

GIORNALE ITALIANO DI CARDIOLOGIA | 2024年 / 25卷 / 02期

关键词：

Key words. Aortic stenosis; Atherosclerosis; Lipoprotein(a); Mitral stenosis; GENOME-WIDE ASSOCIATION; ACUTE CORONARY SYNDROME; OXIDIZED PHOSPHOLIPIDS; ELEVATED LIPOPROTEIN(A); CARDIOVASCULAR RISK; SERIES LIPOPROTEIN; LP(A); APOLIPOPROTEIN(A); INSIGHTS; INHIBITION;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lipoprotein(a) [Lp(a)] is a well-established cardiovascular risk factor, whose relationship with atherosclerotic disease has been confirmed by epidemiological, genome-wide association, Mendelian randomization, and meta-analysis studies. This association is determined by its pro-atherogenic, pro-thrombotic and pro-inflammatory properties. Lp(a) is the most common monogenic risk factor for atherosclerosis, with a prevalence of about 1 in 5 people. Recently, its etiopathogenetic relationship with calcific and degenerative valvular heart diseases, particularly with aortic and mitral stenosis, has been suspected. It has not yet been demonstrated whether its reduction translates into a lower risk of cardiovascular events. Up to now, Lp(a) has been considered a non-modifiable risk factor, as current lipid-lowering drugs have limited effects on its levels. New specific lipid-lowering therapies with high efficacy in reducing circulating Lp(a) levels are being investigated in randomized trials; however, the effects of this reduction on cardiovascular outcomes are still being studied.

引用

页码：76 / 87

页数：12

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