Evolving survival gains in patients with young-onset colorectal cancer and synchronous resectable liver metastases

被引：2

作者：

Maki, Harufumi ^{[1
]}

Haddad, Antony ^{[1
]}

Lendoire, Mateo ^{[1
]}

Newhook, Timothy E. ^{[1
]}

Peacock, Oliver ^{[2
]}

Bednarski, Brian K. ^{[2
]}

Konishi, Tsuyoshi ^{[2
]}

You, Y. Nancy ^{[2
,3
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Colon & Rectal Surg, Houston, TX USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Colon & Rectal Surg, 1515 Holcombe Blvd,Unit 1401, Houston, TX 77030 USA

来源：

EJSO | 2024年 / 50卷 / 04期

关键词：

Colorectal cancer; Liver metastasis; Liver resection; Young -onset colorectal cancer; Survival; RESECTION;

D O I：

10.1016/j.ejso.2024.108057

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We aimed to evaluate the practice and the associated outcomes of surgical treatment for young-onset colorectal cancer (YOCRC) patients presenting with synchronous liver metastases. The study cohort was divided into two groups according to surgery date: 131 patients in the early era (EE, 1998-2011) and 179 in the contemporary era (CE, 2012-2020). The CE had a higher rate of node-positive primary tumors, higher carcinoembryonic antigen level, and lower rate of RAS/BRAF mutations. The CE had higher rates of reverse or combined resection, multidrug prehepatectomy chemotherapy, and two-stage hepatectomy. The median survival was 8.4 years in the CE and 4.3 years in the EE (p = 0.011). On multivariate analysis, hepatectomy in the CE was independently associated with improved overall survival (HR 0.48, p = 0.001). With a combination of perioperative systemic therapy, careful selection of treatment approach, and coordinated resections, durable cure can be achieved in YOCRC patients.

引用

页数：4

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