Butyl Benzyl Phthalate (BBP) disrupts neuromast development in embryonic zebrafish

被引：3
作者：
Paquette, Evelyn [1 ]
Giacalone, John Paul [1 ]
Fumo, Michael [1 ]
Roy, Nicole M. [1 ,2 ]
机构：
[1] Sacred Heart Univ, Dept Biol, Fairfield, CT USA
[2] Sacred Heart Univ, Biol Dept, 5151 Pk Ave, Fairfield, CT 06825 USA
来源：
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2024年 / 106卷
关键词：
Zebrafish; Toxicity; Butyl benzyl phthalate; Neuromast; LATERAL-LINE; SHOALING BEHAVIOR; EXPOSURE; SYSTEM; TOXICITY; HEALTH; IMPACT;
D O I：
10.1016/j.etap.2024.104392
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Butyl benzyl phthalate (BBP) is found in common household and industrial products world-wide. Phthalates are not covalently bound to plastics and continuously leach into the soil, sediment and aquatic environments. The lateral line system of fish is a mechanosensory system composed of neuromasts essential for survival behaviors including rheotaxis, schooling and predator avoidance. Here, we investigated the developmental toxicity of BBP on the developing lateral line neuromasts in zebrafish. Embryos were treated at gastrula stage with BBP and analyzed by DASPEI staining at 4 days post fertilization. We find that BBP negatively affects neuromast development leading to loss of DASPEI signal in neuromasts in a concentration dependent manner.
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