Late-Stage C-H Nitration of Unactivated Arenes by Fe(NO3)3<middle dot>9H2O in Hexafluoroisopropanol

被引：9
作者：
Zheng, Yuzhu [1 ]
Hu, Qi-Qi [1 ]
Huang, Qing [1 ]
Xie, Youwei [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Hubei Key Lab Mat Chem & Serv Failure, Minist Educ,Hubei Key Lab Bioinorgan Chem & Mat Me, Wuhan 430074, Hubei, Peoples R China
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 15期
基金：
中国国家自然科学基金;
关键词：
NITRO-COMPOUNDS; HYDROARYLATION;
D O I：
10.1021/acs.orglett.4c01006
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Operationally simple and generally applicable arene nitration with cheap and easily accessible chemicals has been a long-sought transformation in the synthetic organic community. In this work, we realized this goal with nontoxic and inexpensive Fe(NO3)(3)<middle dot>9H(2)O as the nitro source and easily recyclable solvent hexafluoroisopropanol as the promotor via a network of hydrogen-bonding interactions. As a result of the relative mildness and high reliability of this protocol, late-stage nitration of various highly functionalized natural products and commercially available drugs was realized.
引用
收藏
页码：3316 / 3320
页数：5
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