Metabolomics of male infertility

被引:1
作者
Oluwaloseyi, Amos Victor [1 ,2 ]
Noah, Odeyemi Aduragbemi [1 ]
Oluwatoyin, Ajayi Lydia [3 ]
Gaffar, Yusuff [1 ]
Moses, Olotu [1 ]
Phillips, Akano Oyedayo [4 ]
Onaolapo, Moyinoluwa Comfort [1 ,2 ]
Olateju, Bolade Sylvester [5 ]
Ayodele, Adelakun Ademola [6 ]
Obukohwo, Oyowvi Mega [7 ]
Folorunsho, Ajayi Ayodeji [1 ,2 ,7 ]
机构
[1] Ladoke Akintola Univ Technol, Dept Physiol, Ogbomosho, Oyo, Nigeria
[2] Anchor Biomed Res Inst, Ogbomosho, Oyo, Nigeria
[3] Ladoke Akintola Univ Technol, Dept Biochem, Ogbomosho, Oyo, Nigeria
[4] Babcock Univ, Dept Physiol, Ilishan Remo, Ogun, Nigeria
[5] Florida State Univ, Dept Nutr & Integrat Physiol, Tallahassee, FL USA
[6] Ladoke Akintola Univ Technol, Dept Med Lab Sci, Ogbomosho, Oyo, Nigeria
[7] Adeleke Univ, Dept Physiol, Ede, Osun, Nigeria
关键词
Male reproductive function; Infertility; Metabolomics; Diagnosis; Therapy; SEMINAL PLASMA; MALE-FERTILITY; SEMEN QUALITY; BIOMARKERS; MEN; SPERM; IDENTIFICATION; DELETIONS; SIGNATURES; PROTEOMICS;
D O I
10.1016/j.cca.2024.117850
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
This review explores the use of metabolomics in male infertility. Metabolomics, an evolving omics technology that targets the products of cellular metabolism, is valuable for elucidating underlying pathophysiology of many disorders including male infertility. The identification of reliable biomarkers is essential for accurate diagnosis and for developing precision therapeutics for those afflicted by reproductive dysfunction. Unfortunately, despite significant progress to date, the intricate relationships between these metabolic pathways and male infertility remain elusive. It is clear, however, that additional research is required to more fully characterize the role of metabolomics in this disorder and in the potential development of targeted therapies for precision medicine.
引用
收藏
页数:11
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