Construction of C-P Bonds from Free Cyclobutanone Oximes and Chlorophosphines via Radical-Radical Coupling

被引：7

作者：

Yang, Lulu

Wu, Jiale ^{[1
]}

Li, Yang ^{[1
]}

Tang, Yuhai ^{[1
]}

Li, Jing ^{[1
]}

Xu, Silong ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Ctr Energy Storage Mat & Devices, Sch Chem & Engn Res, Minist Educ, Xian 710049, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 15期

基金：

中国国家自然科学基金;

关键词：

TERVALENT PHOSPHORUS-COMPOUNDS; ACID; REACTIVITY; PHOSPHONYLATION; SUBSTITUTION; DERIVATIVES; INHIBITORS; EFFICIENT;

D O I：

10.1021/acs.orglett.4c00799

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report a catalyst-free reaction of cyclobutanone oximes with chlorophosphines (R2PCl), which forms a fragile C & boxH;N-O-PR2 species that undergoes N-O homolysis, fragmentation, and radical-radical coupling, leading to the formation of cyano-containing phosphine oxides in good yields. The reaction features an in situ activation of cyclobutanone oximes for radical generation, in which R2PCl plays a dual role as both an activator and a reactant.

引用

页码：3208 / 3212

页数：5

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