Mechanism of Cu entry into the brain: many unanswered questions

被引：15

作者：

Roy, Shubhrajit ^{[1
]}

Lutsenko, Svetlana ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Physiol, Sch Med, Baltimore, MD 21218 USA

来源：

NEURAL REGENERATION RESEARCH | 2024年 / 19卷 / 11期

基金：

美国国家卫生研究院;

关键词：

ATOX1; ATP7A; ATP7B; blood-brain barrier; brain; choroid plexus; copper; SLC31A1; MENKES DISEASE; COPPER TRANSPORT; ALZHEIMERS-DISEASE; BARRIER; MOUSE; BLOOD; ZINC; IRON; PROTEIN; ATP7A;

D O I：

10.4103/1673-5374.393107

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Brain tissue requires high amounts of copper (Cu) for its key physiological processes, such as energy production, neurotransmitter synthesis, maturation of neuropeptides, myelination, synaptic plasticity, and radical scavenging. The requirements for Cu in the brain vary depending on specific brain regions, cell types, organism age, and nutritional status. Cu imbalances cause or contribute to several life-threatening neurologic disorders including Menkes disease, Wilson disease, Alzheimer's disease, Parkinson's disease, and others. Despite the well-established role of Cu homeostasis in brain development and function, the mechanisms that govern Cu delivery to the brain are not well defined. This review summarizes available information on Cu transfer through the brain barriers and discusses issues that require further research.

引用

页码：2421 / 2429

页数：9

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