New Triterpenoids and Anti-Inflammatory Constituents from Glinus oppositifolius

被引：4

作者：

Chen, Jih-Jung ^{[1
,2
]}

Yang, Chang-Syun ^{[1
]}

Chen, Yu-Hui ^{[3
]}

Chao, Che-Yi ^{[4
]}

Chen, Yu-Chang ^{[5
]}

Kuo, Yeuh-Hsiung ^{[3
,6
,7
]}

机构：

[1] Natl Yang Ming Chiao Tung Univ, Sch Pharmaceut Sci, Dept Pharm, Taipei 112304, Taiwan

[2] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 404327, Taiwan

[3] China Med Univ, Dept Chinese Pharmaceut Sci & Chinese Med Resource, Taichung 404327, Taiwan

[4] Asia Univ, Dept Food Nutr & Hlth Biotechnol, Taichung 41354, Taiwan

[5] Kaohsiung Med Univ, Coll Pharm, Sch Pharm, Kaohsiung 807377, Taiwan

[6] China Med Univ, Chinese Med Res Ctr, Taichung 404327, Taiwan

[7] Asia Univ, Dept Biotechnol, Taichung 413305, Taiwan

来源：

MOLECULES | 2023年 / 28卷 / 07期

关键词：

Molluginaceae; Glinus oppositifolius; triterpenoids; spergulagenin A; spergulagenin B; spergulagenin C; anti-inflammatory activity; NITRIC-OXIDE; FLAVONOIDS;

D O I：

10.3390/molecules28072903

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three new triterpenoids-spergulagenin B (1), spergulagenin C (2), and spergulagenin D (3)-were isolated from the aerial part of Glinus oppositifolius, along with 17 known compounds (4-20). The structures of these new compounds were identified by spectroscopic and MS analyses. Compounds 3, 5, 19, and 20 were evaluated for inhibition of nitric oxide production in LPS-stimulated RAW 264.7 cells with IC50 values of 17.03, 18.21, 16.30, and 12.64 mu M, respectively. Compounds 3, 5, and 20 exhibited inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 cells with IC50 values of 18.35 +/- 1.34, 17.56 +/- 1.41, and 14.27 +/- 1.29 mu M, respectively.

引用

页数：12

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