Synthesis and in Silico Studies of Novel Potent Kinase Inhibitors: 3-Indoloylquinoline Alkaloid

An exclusive approach towards the synthesis of indoylquinoline alkaloids has been illustrated, the present article describes the synthesis, in Platelet -derived growth factor receptor and silico molecular docking studies of a new compound 3-indolylquinoline-2,4-diol 4. The synthesis of 4 is initiated by a new, efficient, and solvent -free via a thermal Claisen condensation. The structures of the compounds are established using both spectral and analytical data. An in-silico PASS, Swiss ADME-assisted docking approach is found to be suitable for deriving and synthesizing effective receptor tyrosine kinase agents. Claisen ester condensation reaction resulted in the discovery of inexpensive and user-friendly solvents. Structures of the newly synthesized compounds were characterized by FT-IR, H-1 NMR, C-13 NMR, and HRMS (FTMS+PESI) analyses.