Natural variation of TBR confers plant zinc toxicity tolerance through root cell wall pectin methylesterification

被引：6

作者：

Zhong, Kaizhen ^{[1
,2
,3
]}

Zhang, Peng ^{[1
]}

Wei, Xiangjin ^{[1
]}

Platre, Matthieu Pierre ^{[2
]}

He, Wenrong ^{[2
]}

Zhang, Ling ^{[2
]}

Malolepszy, Anna ^{[2
]}

Cao, Min ^{[2
]}

Hu, Shikai ^{[1
]}

Tang, Shaoqing ^{[1
]}

Li, Baohai ^{[2
,4
]}

Hu, Peisong ^{[1
,3
]}

Busch, Wolfgang ^{[2
]}

机构：

[1] China Natl Rice Res Inst, State Key Lab Rice Biol & Breeding, Hangzhou, Zhejiang, Peoples R China

[2] Salk Inst Biol Studies, Plant Mol & Cellular Biol Lab, La Jolla, CA 92037 USA

[3] Jiangxi Agr Univ, Sch Agr Sci, Nanchang, Jiangxi, Peoples R China

[4] Zhejiang Univ, Coll Environm & Resource Sci, MOE Key Lab Environm Remediat & Ecol Hlth, Hangzhou, Zhejiang, Peoples R China

来源：

NATURE COMMUNICATIONS | 2024年 / 15卷 / 01期

基金：

中国国家自然科学基金;

关键词：

TRICHOME-BIREFRINGENCE; ARABIDOPSIS; IRON; DETOXIFICATION; BIOSYNTHESIS; CITRATE; MUTANT; SIZE; FRD3; ZN;

D O I：

10.1038/s41467-024-50106-5

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Zinc (Zn) is an essential micronutrient but can be cytotoxic when present in excess. Plants have evolved mechanisms to tolerate Zn toxicity. To identify genetic loci responsible for natural variation of plant tolerance to Zn toxicity, we conduct genome-wide association studies for root growth responses to high Zn and identify 21 significant associated loci. Among these loci, we identify Trichome Birefringence (TBR) allelic variation determining root growth variation in high Zn conditions. Natural alleles of TBR determine TBR transcript and protein levels which affect pectin methylesterification in root cell walls. Together with previously published data showing that pectin methylesterification increase goes along with decreased Zn binding to cell walls in TBR mutants, our findings lead to a model in which TBR allelic variation enables Zn tolerance through modulating root cell wall pectin methylesterification. The role of TBR in Zn tolerance is conserved across dicot and monocot plant species.

引用

页数：14

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