The contribution of second primary cancers to the mortality of patients with a first primary breast cancer

被引：1

作者：

Goncalves, Elisabete ^{[1
,2
]}

Fontes, Filipa ^{[1
,2
,3
,4
,5
,6
]}

Rodrigues, Jessica Rocha ^{[5
,6
,7
,8
]}

Calisto, Rita ^{[5
,6
,7
,8
]}

Bento, Maria Jose ^{[5
,6
,7
,8
,9
]}

Lunet, Nuno ^{[1
,2
,3
]}

Morais, Samantha ^{[1
,2
]}

机构：

[1] Univ Porto, EPIUnit, Inst Saude Publ, Rua Taipas 135, P-4050091 Porto, Portugal

[2] Lab Invest Integrat & Translac Saude Populac ITR, Porto, Portugal

[3] Fac Med Univ Porto, Dept Ciencias Saude Publ & Forenses & Educ Med, Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal

[4] Inst Portugues Oncol Porto FG, EPE IPO Porto, Ctr Invest CI IPOP, Unidade Invest Enfermagem Oncol, Rua Dr Antonio Bernardino Almeida 865, P-4200072 Porto, Portugal

[5] Inst Portugues Oncol Porto FG, Porto Comprehens Canc Ctr Porto CCC, EPE IPO Porto, Rua Dr Antonio Bernardino Almeida 865, P-4200072 Porto, Portugal

[6] Inst Portugues Oncol Porto FG, RISECI IPOP Rede Invest Saude, EPE IPO Porto, Rua Dr Antonio Bernardino Almeida 865, P-4200072 Porto, Portugal

[7] Inst Portugues Oncol Porto FG, Ctr Invest CI IPOP, Grp Invest Epidemiol Resultados Econ & Gestao Onco, EPE IPO Porto, Porto, Portugal

[8] Inst Portugues Oncol Porto FG, Serv Epidemiol, EPE IPO Porto, Porto, Portugal

[9] ICBAS Inst Ciencias Biomed Abel Salazar Univ Porto, Dept Estudos Populacoes, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2024年 / 207卷 / 02期

关键词：

Breast neoplasms; Epidemiology; Population register; Mortality; Second primary neoplasm; PRIMARY MALIGNANCIES; SURVIVAL; PORTUGAL; WOMEN;

D O I：

10.1007/s10549-024-07361-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose Second primary cancers (SPCs) are estimated to affect nearly 5% of patients with breast cancer within 10 years of their diagnosis. This study aimed to estimate the contribution of SPCs to the mortality of patients with a breast first primary cancer (FPC). Methods A population-based cohort of 17,210 patients with a breast FPC diagnosed between 2000 and 2010 was followed for SPCs (31/12/2015) and vital status (30/06/2021). Patients diagnosed with an SPC (265 synchronous and 897 metachronous, <= 1 and > 1 year after the FPC, respectively) were matched (1:3, by five-year age group and year of breast FPC diagnosis) to those without an SPC and alive when the corresponding SPC was diagnosed. Results Significantly higher hazards of death were found among patients with an SPC [hazard ratio of 1.56, 95% confidence interval (CI) 1.29-1.89 for synchronous SPCs; and 2.85, 95%CI 2.56-3.17 for metachronous SPCs] compared to patients with a breast FPC only. Estimates were higher for synchronous lung, stomach, non-Hodgkin lymphoma and breast SPCs, and metachronous liver, stomach, ovary, lung, rectum, corpus uteri, colon, breast, and non-Hodgkin lymphoma SPCs. The 15-year cumulative mortality was 59.5% for synchronous SPCs and 68.7% for metachronous SPCs, which was higher than in patients with a breast FPC only (43.6% and 44.8%, respectively). Conclusions In Northern Portugal, patients with an SPC following a breast FPC have a higher mortality compared with patients with a breast FPC only.

引用

页码：323 / 330

页数：8

共 26 条

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