Transdermal delivery of IBU-PLGA nanoparticles with dissolving microneedle array patch

被引：8

作者：

Yang, Fan ^{[1
]}

Wang, Wei ^{[2
]}

Zhou, Jing ^{[3
]}

Yu, Zhoubing ^{[4
]}

An, Mingwei ^{[1
]}

He, Wenxuan ^{[1
]}

Xue, Yun ^{[5
]}

Chen, Fan ^{[1
]}

机构：

[1] Hubei Univ, Life Sci Sch, State Key Lab Biocatalysis & Enzyme Engn, 368 Youyi Rd, Wuhan 430062, Hubei, Peoples R China

[2] Dongguan Changan Hosp, Dept Lab Med, Dongguan 523843, Guangdong, Peoples R China

[3] Wuhan Pulm Hosp, Clin Lab, 28 Baofeng Rd, Wuhan 430030, Hubei, Peoples R China

[4] Wuhan Biocause Pharmaceut Dev Co Ltd, Wuhan 430056, Peoples R China

[5] Henan Univ Sci & Technol, Coll Med Technol & Engn, Lab Med Engn, Luoyang 471003, Peoples R China

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2024年 / 95卷

关键词：

Ibuprofen; Nanoparticles; Dissolving microneedles; Transdermal delivery; CHRONIC KNEE PAIN; IN-VITRO; ORAL IBUPROFEN; VIVO; PENETRATION; ABSORPTION; TOXICITY; PRESSURE; RELEASE; POWDER;

D O I：

10.1016/j.jddst.2024.105528

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

There are few systematic studies using microneedles to deliver ibuprofen through the skin. In this study, Ibuprofen was encapsulated in poly (lactide-co-Glycolide) (PLGA) network to form nanoparticles(IBU-NPs), then the IBU-NPs were mixed with Sodium Hyaluronate to fabricate dissolving microneedles array patch (MNP) and applied in mice model to observe its effect. In mouse model, IBU-NPs microneedles could effectively deliver ibuprofen to mice and significantly reduced the number of writhe, significantly reduced the mRNA of CGRP, COX-2, TNF-alpha, IL-1 beta, IL-6 and increased the mRNA of opioid receptor. This study introduces a rapid microneedle transdermal delivery technique for ibuprofen nanoparticles and confirms its effectiveness in terms of the mechanism of action.

引用

页数：10

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