Melanoma extracellular vesicles inhibit tumor growth and metastasis by stimulating CD8 T cells

被引：2
作者：
Dan, Yuxi [1 ,2 ]
Ma, Jing [1 ,2 ]
Long, Yuqing [1 ,2 ]
Jiang, Yao [1 ,2 ]
Fang, Liaoqiong [1 ,3 ]
Bai, Jin [1 ,2 ]
机构：
[1] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China
[2] Chongqing Med Univ, Chongqing Key Lab Biomed Engn, Chongqing 400016, Peoples R China
[3] Natl Engn Res Ctr Ultrasound Med, Chongqing 401121, Peoples R China
来源：
MOLECULAR IMMUNOLOGY | 2024年 / 169卷
关键词：
Extracellular vesicles; Melanoma; CD8 T cells; Dendritic cells; DENDRITIC CELLS; VACCINE;
D O I：
10.1016/j.molimm.2024.03.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tumor cell-derived extracellular vesicles (EVs) play a crucial role in mediating immune responses by carrying and presenting tumor antigens. Here, we suggested that melanoma EVs triggered cytotoxic CD8 T cell-mediated inhibition of tumor growth and metastasis. Our results indicated that immunization of mice with melanoma EVs inhibited melanoma growth and metastasis while increasing CD8 T cells and serum interferon gamma (IFN-gamma) in vivo. In vitro experiments showed that melanoma EV stimulates dendritic cells (DCs) maturation, and mature dendritic cells induce T lymphocyte activation. Thus, tumor cell-derived EVs can generate anti-tumor immunity in a prophylactic setting and may be potential candidates for cell-free tumor vaccines.
引用
收藏
页码：78 / 85
页数：8
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