Evaluation of the prognostic impact of pathologic tumor regression grade on patients with colorectal cancer after preoperative chemoradiotherapy

被引：0

作者：

Nakao, Eiichi ^{[1
,2
,3
]}

Honda, Michitaka ^{[2
,3
]}

Uesugi, Noriyuki ^{[1
,4
]}

Osakabe, Mitsumasa ^{[4
]}

Sato, Ayaka ^{[4
]}

Todate, Yukitoshi ^{[2
,3
]}

Yaegashi, Mizunori ^{[5
]}

Takano, Yoshinao ^{[3
]}

Sasaki, Akira ^{[5
]}

Kono, Koji ^{[6
]}

Sugai, Tamotsu ^{[1
,4
,7
]}

机构：

[1] Southern Tohoku Gen Hosp, Diagnost Pathol Ctr, Koriyama, Fukushima, Japan

[2] Fukushima Med Univ, Dept Minimally Invas Surg & Med Oncol, Fukushima, Japan

[3] Southern Tohoku Gen Hosp, Div Surg, Koriyama, Fukushima, Japan

[4] Iwate Med Univ, Sch Med, Dept Mol Diagnost Pathol, Yahaba, Japan

[5] Iwate Med Univ, Sch Med, Dept Surg, Yahaba, Japan

[6] Fukushima Med Univ, Dept Gastrointestinal Surg, Fukushima, Japan

[7] Iwate Med Univ, Dept Mol Diagnost Pathol, 2-1-1 Shiwagunyahabachou, Yahaba 0283695, Japan

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2024年 / 129卷 / 08期

关键词：

chemoradiotherapy; cut-off value; prognosis; rectal cancer; tumor regression grade; ADVANCED RECTAL-CANCER; LONG-TERM-OUTCOMES; COMPLETE RESPONSE; THERAPY; CHEMOTHERAPY; METASTASES; COLON;

D O I：

10.1002/jso.27662

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The prognostic value of the pathological response to preoperative chemoradiotherapy (CRT) in rectal cancer (RC) remains unknown. Objectives: We aimed to assess the predictive value of the response to CRT that was derived from an evaluation of the histological findings (whole-section vs. representative-section sampling) and attempted to determine an objective cut-off value for the tumor regression grade (TRG). Methods: We examined the association of the TRG with the outcomes (recurrence-free survival [RFS] and overall survival [OS]) of 78 patients with RC. Patients with RC treated with preoperative CRT were divided into development (30 cases) and validation (48 cases) cohorts. The TRG was classified as grades I (Ia, Ib), II, and III. The cut-off value was determined by receiver operating characteristic (ROC) curve analysis. Results: The TRG determined from whole-section sampling versus representative-section sampling was more strongly correlated with patient survival. We found that in both cohorts, patients with a cut-off value of <73% had a poor prognosis. Finally, the cut-off value was found to be an independent predictive factor in both univariate and multivariate analysis. Conclusions: The TRG that was used to evaluate patients with RC who underwent preoperative CRT was an independent prognostic factor for outcome.

引用

页码：1521 / 1533

页数：13

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