Direct stimulation of anterior insula and ventromedial prefrontal cortex disrupts economic choices

被引：2

作者：

Romane Cecchi ^{[1
]}

Antoine Collomb-Clerc ^{[5
]}

Inès Rachidi ^{[6
]}

Lorella Minotti ^{[1
]}

Philippe Kahane ^{[7
]}

Mathias Pessiglione ^{[1
]}

Julien Bastin ^{[2
]}

机构：

[1] Univ. Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences, Grenoble

[2] Neurology Department, University Hospital of Grenoble, Grenoble

[3] Motivation, Brain and Behavior (MBB) team, Paris Brain Institute, Pitié-Salpêtrière Hospital, Paris

[4] Université de Paris, Paris

[5] Laboratoire de Neurosciences Cognitives et Computationnelles, Institut National de la Santé et de la Recherche Médicale, Paris

[6] Département d’Études Cognitives, École Normale Supérieure, Université Paris Sciences et Lettres, Paris

[7] NeuroX Institute and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne

来源：

Nature Communications | / 15卷 / 1期

关键词：

D O I：

10.1038/s41467-024-51822-8

中图分类号：

学科分类号：

摘要：

Neural activity within the ventromedial prefrontal cortex (vmPFC) and anterior insula (aIns) is often associated with economic choices and confidence. However, it remains unclear whether these brain regions are causally related to these processes. To address this issue, we leveraged intracranial electrical stimulation (iES) data obtained from patients with epilepsy performing an economic choice task. Our results reveal opposite effects of stimulation on decision-making depending on its location along a dorso-ventral axis within each region. Specifically, stimulation of the ventral subregion within aIns reduces risk-taking by increasing participants’ sensitivity to potential losses, whereas stimulation of the dorsal subregion of aIns and the ventral portion of the vmPFC increases risk-taking by reducing participants’ sensitivity to losses. Moreover, stimulation of the aIns consistently decreases participants’ confidence, regardless of its location within the aIns. These findings suggest the existence of functionally dissociated neural subregions and circuits causally involved in accepting or avoiding challenges. © The Author(s) 2024.

引用

共 74 条

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