Prognostic implications of cGAS and STING gene expression in acute myeloid leukemia

被引：3

作者：

Chen, Qiuling ^{[1
,2
,3
]}

Hong, Yan ^{[2
,3
]}

Chen, Weifeng ^{[4
]}

Lin, Feng ^{[2
,3
,4
]}

Zeng, Jiawei ^{[1
,2
,3
]}

Huang, Yueting ^{[2
,3
]}

Zhang, Li ^{[2
,3
]}

Yao, Jingwei ^{[2
,3
]}

Xu, Bing ^{[2
,3
]}

机构：

[1] Fujian Med Univ, Sch Clin Med, Fuzhou, Fujian, Peoples R China

[2] Xiamen Univ, Affiliated Hosp 1, Sch Med, Dept Hematol, Xiamen, Peoples R China

[3] Xiamen Univ, Inst Hematol, Sch Med, Xiamen, Peoples R China

[4] Shantou Cent Hosp, Dept Hematol, Shantou, Guangdong, Peoples R China

来源：

EXPERIMENTAL BIOLOGY AND MEDICINE | 2024年 / 249卷

基金：

中国国家自然科学基金;

关键词：

cGAS; STING; expression; prognosis; acute myeloid leukemia; PATHWAY; CANCER; AML; ACTIVATION; PROMOTES; IMMUNITY; TUMORS; CELLS; NRAS;

D O I：

10.3389/ebm.2024.10108

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Acute myeloid leukemia (AML) is one of the most threatening hematological malignances. cGAS-STING pathway plays an important role in tumor immunity and development. However, the prognostic role of cGAS-STING pathway in AML remains unknown. Firstly, The expression of cGAS and STING was analyzed by bioinformatics analysis. Subsequently, Bone marrow samples were collected from 120 AML patients and 15 healthy individuals in an independent cohort. The cGAS and STING expression was significantly elevated in AML patients compared with healthy controls. Patients with high cGAS and STING expression had a higher NRAS/KRAS mutation rate and lower complete remission (CR) rate. High cGAS and STING expression was significantly associated with lower overall survival (OS) and disease-free survival (DFS). Our findings revealed that the expression levels of cGAS and STING in AML are elevated. High expression of cGAS and STING correlated with worse OS and DFS and may be a useful biomarker for inferior prognosis in AML patients.

引用

页数：9

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