Preparation of Ultra-fast Temperature Responsive Nanofibrous Hydrogel and Application in Controllable Drug Release

被引：0
|
作者：
Zheng X. [1 ,2 ]
Zha L. [1 ,2 ]
机构：
[1] State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai
[2] College of Materials Science and Engineering, Donghua University, Shanghai
来源：
Cailiao Yanjiu Xuebao/Chinese Journal of Materials Research | 2020年 / 34卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Controllable drug release; Organic polymer materials; Static electrospinning; Temperature responsive nanofibrous hydrogel;
D O I：
10.11901/1005.3093.2019.493
中图分类号：
学科分类号：
摘要：
The nanofibers were firstly prepared by static electrospinning process using the fiberforming copolymer synthesized from N-isopropylacrylamide and N-methylol acrylamide, and then they were shortened and dispersed in tert-butanol by high-speed stirring. Finally, the shortened nanofibers were assembled into nanofibrous hydrogel with hierarchical porous structure by the processes of freeze drying and followed heat treatment. The resultant nanofibrous hydrogel in aqueous medium holds excellent stability, compression resilience and remarkable temperature-responsiveness. When the temperature of an aqueous medium changed alternately between 20℃ and 55℃, in which the nanofibrous hydrogel reached its swelling- and deswelling-equilibrium state within 34 s and 45 s respectively, exhibiting ultra-fast temperature responsiveness. In vitro drug release experiment results show that when the temperature of the phosphate buffered solution of pH7.4 is altered alternately between 15℃ and 47℃ the immersed dextran (model drug) loaded nanofibrous hydrogel can controllably release the drug by ''on/off '' mode. © All right reserved.
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页码：452 / 458
页数：6
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