Ruthenium-Catalyzed Regioselective C7-H Arylation of 2-(Het)aryl[1,2,4]triazolo[1,5-a]pyrimidines with Aryl Halides

被引：1

作者：

Shepelenko, K. E. ^{[1
]}

Gnatiuk, I. G. ^{[1
]}

Chernyshev, V. M. ^{[1
]}

机构：

[1] Platov South Russian State Polytech Univ, Novocherkassk 346428, Russia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 60卷 / 06期

关键词：

ruthenium catalysis; C-H arylation; 1,2,4]triazolo[1,5-a]pyrimidines; H BOND ACTIVATION; ENABLES; AMETOCTRADIN; POTENT;

D O I：

10.1134/S1070428024060095

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Unusual direction of the C-H arylation of 2-(het)aryl[1,2,4]triazolo[1,5-a]pyrimidines with (het)aryl halides under catalysis by ruthenium(II) complexes has been revealed. The reaction involved activation of the C-7-H bond rather than the C-alpha-H bond of the (het)aryl substituent at C-2 of the triazolopyrimidine core. The arylation of 2-substituted [1,2,4]triazolo[1,5-a]pyrimidines with (het)aryl bromides afforded a series of 7-(het)aryl derivatives in good yields.

引用

页码：1042 / 1050

页数：9

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