Terpenoids from Alpinia galanga and their acetylcholinesterase inhibitory activity

被引：1
|
作者：
Zhou, Bo [1 ,2 ,3 ]
Guo, Meng-Jia [1 ,2 ,3 ]
Zhao, Xin-Man [1 ,2 ,3 ]
Li, Xiao-Long [1 ,2 ,3 ]
Liu, Shao-Huan [1 ,2 ,3 ]
Shen, Xiang-Chun [1 ,2 ,3 ]
Zhang, Nen-Ling [1 ,2 ,3 ]
机构：
[1] Guizhou Med Univ, Sch Pharmaceut Sci, State Key Lab Funct & Applicat Med Plants, Guiyang, Peoples R China
[2] Guizhou Med Univ, High Efficacy Applicat Nat Med Resources Engn Ctr, Sch Pharmaceut Sci, Guiyang, Peoples R China
[3] Guizhou Med Univ, Sch Pharmaceut Sci, Key Lab Optimal Utilizat Nat Med Resources, Guiyang, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2024年
关键词：
Alpinia galanga; sesquiterpenoid; diterpenoid; acetylcholinesterase; inhibitory activity; SEEDS; SESQUITERPENES; DITERPENES; RHIZOMES;
D O I：
10.1080/14786419.2024.2346269
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new labdane diterpene (1), two new norsesquiterpenoids (2-3), as well as eight known terpenoids (4-11) were isolated from the seeds of Alpinia galanga (Zingiberaceae). Their structures and absolute configurations were elucidated by 1D, 2D NMR, MS, and comparison of their experimental and calculated electronic circular dichroism (ECD). The acetylcholinesterase (AChE) inhibitory activities of all the isolated compounds (1-11) were evaluated and the result showed that compounds 6 and 9 had inhibitory activity against AChE, with IC50 values at 295.70 and 183.91 mu M, whereas other compounds did not show any inhibitory activity.<br /> [GRAPHICS]
引用
收藏
页数：8
相关论文
共 50 条
  • [1] α-Glucosidase inhibitory activities of aromatic compounds from the rhizomes of Alpinia galanga
    Cheng, Yueh-Hung
    Chen, Po-Chun
    Dlamini, Zakhele M.
    Li, Jia-Wei
    Dlamini, Bongani S.
    Chen, Yu-Kuo
    Chang, Chi-, I
    MEDICINAL CHEMISTRY RESEARCH, 2025, 34 (02) : 466 - 475
  • [2] Melanogenesis inhibitory activity of a 7-O-9′-linked neolignan from Alpinia galanga fruit
    Manse, Yoshiaki
    Ninomiya, Kiyofumi
    Nishi, Ryosuke
    Kamei, Iyori
    Katsuyama, Yushi
    Imagawa, Takahito
    Chaipech, Saowanee
    Muraoka, Osamu
    Morikawa, Toshio
    BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 24 (23) : 6215 - 6224
  • [3] Biological activity of Alpinia galanga root tubers
    Dharmaratne, H. R. W.
    Tekwani, B. L.
    Jacob, M.
    Nanayakkara, N. P. D.
    PLANTA MEDICA, 2012, 78 (11) : 1237 - 1237
  • [4] Labdane-Type Diterpenes, Galangalditerpenes A-C, with Melanogenesis Inhibitory Activity from the Fruit of Alpinia galanga
    Manse, Yoshiaki
    Ninomiya, Kiyofumi
    Nishi, Ryosuke
    Hashimoto, Yoshinori
    Chaipech, Saowanee
    Muraoka, Osamu
    Morikawa, Toshio
    MOLECULES, 2017, 22 (12):
  • [5] Evaluation of Immunomodulatory activity of phytochemicals from Alpinia galanga and Alpinia nigra for potent immunostimulatory agent in chemotherapy
    Swagatikal, Dash
    Achary, Gopinath K.
    Shikha, Singh
    RESEARCH JOURNAL OF BIOTECHNOLOGY, 2023, 18 (11): : 49 - 57
  • [6] THE ESSENTIAL OIL OF GREATER GALANGA (ALPINIA-GALANGA) FROM MALAYSIA
    DEPOOTER, HL
    OMAR, MN
    COOLSAET, BA
    SCHAMP, NM
    PHYTOCHEMISTRY, 1985, 24 (01) : 93 - 96
  • [7] Antinociceptive activity of ethanolic extract of rhizomes of Alpinia galanga
    Shivgunde, P. P.
    Shah, P.
    Jain, D. P.
    Singhai, A. K.
    Somani, R. S.
    INDIAN JOURNAL OF PHARMACOLOGY, 2008, 40 : 172 - 172
  • [8] ANTITUMOR PRINCIPLES FROM ALPINIA-GALANGA
    ITOKAWA, H
    MORITA, H
    SUMITOMO, T
    TOTSUKA, N
    TAKEYA, K
    PLANTA MEDICA, 1987, (01) : 32 - 33
  • [9] A New Phenylalkanoid from the Rhizomes of Alpinia galanga
    G. C. Huang
    C. L. Kao
    W. J. Li
    S. T. Huang
    H. T. Li
    C. Y. Chen
    Chemistry of Natural Compounds, 2018, 54 : 1072 - 1075
  • [10] Galangoisoflavonoid Isolated from Rhizomes of Alpinia Galanga
    Jaju, S. B.
    Indurwade, N. H.
    Sakarkar, D. M.
    Fuloria, N. K.
    Ali, M.
    Basu, S. P.
    PHARMACOGNOSY MAGAZINE, 2009, 5 (19) : 209 - 212
12345