The role of fibrosis in cardiomyopathies: An opportunity to develop novel biomarkers of disease activity

被引：6

作者：

Angeli, Elisavet ^{[1
,2
]}

Jordan, Maria ^{[3
,4
]}

Otto, Mandy ^{[3
,4
]}

Stojanovic, Stevan D. ^{[5
,6
]}

Karsdal, Morten ^{[2
]}

Bauersachs, Johann ^{[5
]}

Thum, Thomas ^{[3
,4
,6
]}

Fiedler, Jan ^{[3
,4
]}

Genovese, Federica ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Biomed Sci, Copenhagen, Denmark

[2] Nordic Biosci A S, Herlev, Denmark

[3] Fraunhofer Inst Toxicol & Expt Med ITEM, Hannover, Germany

[4] Fraunhofer Cluster Excellence Immune Mediated Dis, Hannover, Germany

[5] Hannover Med Sch, Dept Cardiol & Angiol, Hannover, Germany

[6] Hannover Med Sch, Inst Mol & Translat Therapeut Strategies, Hannover, Germany

来源：

MATRIX BIOLOGY | 2024年 / 128卷

基金：

欧洲研究理事会;

关键词：

Cardiomyopathies; Fibrosis; Extracellular matrix; Biomarkers; MYOCARDIAL INTERSTITIAL FIBROSIS; VENTRICULAR NON-COMPACTION; EXTRACELLULAR-MATRIX; HEART-FAILURE; DILATED CARDIOMYOPATHY; MAGNETIC-RESONANCE; FIBROBLAST ACTIVATION; NONINVASIVE DETECTION; AORTIC-STENOSIS; ANGIOTENSIN-II;

D O I：

10.1016/j.matbio.2024.02.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cardiomyopathies encompass a spectrum of heart disorders with diverse causes and presentations. Fibrosis stands out as a shared hallmark among various cardiomyopathies, reflecting a common thread in their pathogenesis. This prevalent fibrotic response is intricately linked to the consequences of dysregulated extracellular matrix (ECM) remodeling, emphasizing its significance in the development and progression the disease. This review explores the ECM involvement in various cardiomyopathies and its impact on myocardial stiffness and fibrosis. Additionally, we discuss the potential of ECM fragments as early diagnosis, prognosis, and risk stratification. Biomarkers deriving from turnover of collagens and other ECM proteins hold promise in clinical applications. We outline current clinical management, future directions, and the potential for personalized ECMtargeted therapies with specific focus on microRNAs. In summary, this review examines the role of the fibrosis in cardiomyopathies, highlighting the potential of ECM -derived biomarkers in improving disease management with implications for precision medicine.

引用

页码：65 / 78

页数：14

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