Anti-MDA5 Antibody-Positive Clinically Amyopathic Dermatomyositis Associated With Multiple Heterologous Carcinomas: A Case Report

被引：0

作者：

Nakano, Yoshio ^{[1
]}

Nishida, Koji ^{[1
]}

Okamoto, Norio ^{[1
]}

Gohma, Iwao ^{[1
]}

Yasuhara, Yumiko ^{[2
]}

机构：

[1] Sakai City Med Ctr, Resp Med, Osaka, Japan

[2] Sakai City Med Ctr, Pathol, Osaka, Japan

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2024年 / 16卷 / 02期

关键词：

heterochronous; cancer; interstitial lung disease; anti-mda5; antibody; dermatomyositis; INTERSTITIAL LUNG-DISEASE; MYOSITIS; CANCER;

D O I：

10.7759/cureus.54660

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dermatomyositis (DM), an autoimmune disorder, is linked to increased malignancy risk. A 53 -year -old man with anti -melanoma differentiation -associated gene 5 (MDA5)-positive clinically amyopathic dermatomyositis (CADM) and rapidly progressing interstitial lung disease (RP-ILD) developed heterochronous gastric and colorectal cancers. Early endoscopic screenings led to successful curative resections, preventing recurrence. Despite low cancer incidence assumptions in patients with anti-MDA5positive RP-ILD, this case advocates for reevaluation and periodic cancer screenings to enhance management, considering the improved survival with intensive therapy. Vigilance for multiple carcinomas at various time points is vital in CADM management.

引用

页数：6

共 14 条

[1] A Case in Which Breast Cancer Developed at the Same Time As Dermatomyositis, and the Onset of New Cancer Was Able to Be Predicted by the Exacerbating Skin Symptoms and Parallel Increase in the Anti-TIF1-γ Antibody Levels [J].

Akagi, Hideko ;

Wada, Tatsuhiko .

INTERNAL MEDICINE, 2023, 62 (20) :3057-3062

[2]

BARNES BE, 1976, ANN INTERN MED, V84, P68, DOI 10.7326/0003-4819-84-1-68

[3] Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy [J].

Casciola-Rosen, L ;

Nagaraju, K ;

Plotz, P ;

Wang, K ;

Levine, S ;

Gabrielson, E ;

Corse, A ;

Rosen, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (04) :591-601

[4] Cancer risks of dermatomyositis and polymyositis: a nationwide cohort study in Taiwan [J].

Chen, Yi-Ju ;

Wu, Chun-Ying ;

Huang, Yu-Lin ;

Wang, Chang-Bi ;

Shen, Jui-Lung ;

Chang, Yun-Ting .

ARTHRITIS RESEARCH & THERAPY, 2010, 12 (02)

[5] Lymphocyte immunophenotyping in inflammatory myositis: a review [J].

Franco, Chiara ;

Gatto, Mariele ;

Iaccarino, Luca ;

Ghirardello, Anna ;

Doria, Andrea .

CURRENT OPINION IN RHEUMATOLOGY, 2021, 33 (06) :522-528

[6]

Ghazi E, 2013, CLIN EXP RHEUMATOL, V31, P128

[7]

Hashimoto Mikiko, 2004, Nihon Rinsho Meneki Gakkai Kaishi, V27, P427

[8]

Hashimoto S., 2018, Journal of the Japanese Society of Gastroenterological Surgery, V51, P365, DOI [10.5833/jjgs.2017.0094, DOI 10.5833/JJGS.2017.0094]

[9] Anti-MDA5 and anti-TIF1-γ antibodies have clinical significance for patients with dermatomyositis [J].

Hoshino, Kei ;

Muro, Yoshinao ;

Sugiura, Kazumitsu ;

Tomita, Yasushi ;

Nakashima, Ran ;

Mimori, Tsuneyo .

RHEUMATOLOGY, 2010, 49 (09) :1726-1733

[10]

Ichiyasu H, 2017, RESPIR MED CASE REP, V20, P51, DOI 10.1016/j.rmcr.2016.11.015

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