Evaluating p-tau217 and p-tau231 as Biomarkers for Early Diagnosis and Differentiation of Alzheimer's Disease: A Narrative Review

被引：11

作者：

Jarek, Dorian Julian ^{[1
]}

Mizerka, Hubert ^{[1
]}

Nuszkiewicz, Jaroslaw ^{[2
]}

Szewczyk-Golec, Karolina ^{[2
]}

机构：

[1] Nicolaus Copernicus Univ Torun, Fac Med, Dept Med Biol & Biochem, Student Res Club Med Biol & Biochem,Ludwik Rydygie, PL-85092 Bydgoszcz, Poland

[2] Nicolaus Copernicus Univ Torun, Fac Med, Dept Med Biol & Biochem, Ludwik Rydygier Coll Medicum Bydgoszcz, PL-85092 Bydgoszcz, Poland

来源：

BIOMEDICINES | 2024年 / 12卷 / 04期

关键词：

Alzheimer's disease; amyloid plaques; biomarker; diagnosis; neurodegenerative diseases; neurofibrillary tangles; p-tau; p-tau217; p-tau231; tau proteins; MODIFIABLE RISK-FACTORS; TAU-PROTEIN; ASSOCIATION WORKGROUPS; NATIONAL INSTITUTE; PLASMA P-TAU217; A-BETA; PHOSPHORYLATION; RECOMMENDATIONS; GUIDELINES; ACCUMULATION;

D O I：

10.3390/biomedicines12040786

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The escalating prevalence of Alzheimer's disease (AD) highlights the urgent need to develop reliable biomarkers for early diagnosis and intervention. AD is characterized by the pathological accumulation of amyloid-beta plaques and tau neurofibrillary tangles. Phosphorylated tau (p-tau) proteins, particularly p-tau217 and p-tau231, have been identified as promising biomarker candidates to differentiate the disease progression from preclinical stages. This narrative review is devoted to a critical evaluation of the diagnostic accuracy, sensitivity, and specificity of p-tau217 and p-tau231 levels in the detection of AD, measured in plasma, serum, and cerebrospinal fluid, compared to established biomarkers. Additionally, the efficacy of these markers in distinguishing AD from other neurodegenerative disorders is examined. The significant advances offered by p-tau217 and p-tau231 in AD diagnostics are highlighted, demonstrating their unique utility in early detection and differential diagnosis. This comprehensive analysis not only confirms the excellent diagnostic capabilities of these markers, but also deepens the understanding of the molecular dynamics of AD, contributing to the broader scientific discourse on neurodegenerative diseases. This review is aimed to provide key information for researchers and clinicians across disciplines, filling interdisciplinary gaps and highlighting the role of p-tau proteins in revolutionizing AD research and clinical practice.

引用

页数：24

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