Direct and indirect impact of the COVID-19 pandemic on the survival of kidney transplant recipients: A national observational study in France

被引:1
|
作者
Leye, Elhadji [1 ,7 ]
Delory, Tristan [1 ,2 ,3 ]
El Karoui, Khalil [4 ]
Espagnacq, Maude [5 ]
Khlat, Myriam [3 ]
Le Coeur, Sophie [3 ]
Lapidus, Nathanael [6 ]
Hejblum, Gilles [1 ]
机构
[1] Sorbonne Univ, Inst Pierre Louis Epidemiol & Sante Publ, INSERM, Paris, France
[2] Ctr Hosp Annecy Genevois, Epagny Metz Tessy, France
[3] French Inst Demog Studies INED, Mortal Hlth & Epidemiol Unit, Aubervilliers, France
[4] Sorbonne Univ, Hop Tenon, AP HP, INSERM U1155,Serv Nephrol, Paris, France
[5] Inst Res & Informat Hlth Econ IRDES, Paris, France
[6] Sorbonne Univ, Inst Pierre Louis dEpidemiol & Sante Publ, St Antoine Hosp, AP HP,Unit Publ Hlth,INSERM, F-75001 Paris, France
[7] Sorbonne Univ, UMR S 1136, INSERM, 27 Rue Chaligny, F-75012 Paris, France
关键词
COVID-19; epidemiology; kidney; mortality; proportional hazard models; transplants; SOLID-ORGAN; DIALYSIS; MORTALITY; TIME; RISK;
D O I
10.1016/j.ajt.2023.10.017
中图分类号
R61 [外科手术学];
学科分类号
摘要
During the pandemic period, health care systems were substantially reorganized for managing COVID-19 cases. Corresponding consequences on persons with chronic diseases remain insufficiently documented. This observational cohort study investigated the direct and indirect impact of the pandemic period on the survival of kidney transplant recipients (KTR). Using the French National Health Data System, incident persons with endstage kidney disease between 2015 and 2020, and who received a kidney transplant during this period were included and followed up from their transplantation date to December 31, 2021. The survival of KTR during the prepandemic and pandemic periods was investigated using Cox models with time -dependent covariates. There were 10 637 KTR included in the study, with 324 and 430 deaths observed during the prepandemic and pandemic periods, respectively. The adjusted risk of death during the pandemic period was similar to that observed during the prepandemic period (hazard ratio [HR] [95% confidence interval]: 0.92 [0.77-1.11]), COVID-19-related hospitalization was associated with an increased risk of death (HR: 10.62 [8.46-13.33]), and a third vaccine dose was associated with a lower risk of death (HR: 0.42 [0.30-0.57]). The pandemic period was not associated with an indirect higher risk of death in KTR with no COVID-19-related hospitalization.
引用
收藏
页码:479 / 490
页数:12
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