Ad26.M.Env ZIKV vaccine protects pregnant rhesus macaques and fetuses against Zika virus infection

被引：1
作者：
Martinot, Amanda J. [1 ,2 ]
Cox, Freek [3 ]
Abbink, Peter [1 ]
Hecht, Jonathan L. [4 ]
Bronson, Roderick [5 ]
Borducchi, Erica N. [1 ]
Rinaldi, William J. [6 ]
Ferguson, Melissa J. [6 ]
de la Barrera, Rafael A. [7 ]
Zahn, Roland [3 ]
Van der Fits, Leslie [3 ]
Barouch, Dan H. [1 ,8 ]
机构：
[1] Harvard Med Sch, Ctr Virol & Vaccine Res, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA
[2] Tufts Univ, Cummings Sch Vet Med, Dept Infect Dis & Global Hlth & Comparat Pathobiol, North Grafton, MA 01536 USA
[3] Janssen Vaccines & Prevent, Leiden, Netherlands
[4] Beth Israel Deaconess Med Ctr, Div Anat Pathol, Boston, MA USA
[5] Harvard Med Sch, Boston, MA USA
[6] Alphagenesis, Yemassee, SC USA
[7] Walter Reed Army Inst Res, Silver Spring, MD USA
[8] MIT & Harvard, Ragon Inst MGH, Cambridge, MA 02139 USA
来源：
NPJ VACCINES | 2024年 / 9卷 / 01期
关键词：
DOUBLE-BLIND; IMMUNOGENICITY; SAFETY; PREVENTION; EFFICACY; GUIDANCE; PHASE-1; REGIMEN;
D O I：
10.1038/s41541-024-00927-8
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
At the start of the Zika virus (ZIKV) epidemic in 2015, ZIKV spread across South and Central America, and reached parts of the southern United States placing pregnant women at risk for fetal microcephaly, fetal loss, and other adverse pregnancy outcomes associated with congenital ZIKA syndrome (CZS). For this reason, testing of a safe and efficacious ZIKV vaccine remains a global health priority. Here we report that a single immunization with Ad26.M.Env ZIKV vaccine, when administered prior to conception, fully protects pregnant rhesus macaques from ZIKV viral RNA in blood and tissues with no adverse effects in dams and fetuses. Furthermore, vaccination prevents ZIKV distribution to fetal tissues including the brain. ZIKV associated neuropathology was absent in offspring of Ad26.M.Env vaccinated dams, although pathology was limited in fetuses from non-immunized, challenged dams. Vaccine efficacy is associated with induction of ZIKV neutralizing antibodies in pregnant rhesus macaques. These data suggest the feasibility of vaccine prevention of CZS in humans.
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页数：12
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