Adrenergic signaling dampens T cell activity during chronic infection and cancer

被引：4

作者：

Cox, Maureen A. ^{[1
,2
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol & Immunol, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Stephenson Canc Ctr, Oklahoma City, OK 73104 USA

来源：

TRENDS IN NEUROSCIENCES | 2024年 / 47卷 / 03期

关键词：

D O I：

10.1016/j.tins.2023.12.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Stress contributes to infection and cancer susceptibility, but the mediating mechanisms are still being elucidated. CD8 T cells are critical players in antiviral and antitumor immune responses. A recent study by Globig et al., together with a growing body of literature, link norepinephrine produced during the stress response to CD8 T cell dysfunction.

引用

页码：165 / 166

页数：2

共 10 条

[1] Highlighting the Potential for Chronic Stress to Minimize Therapeutic Responses to Radiotherapy through Increased Immunosuppression and Radiation Resistance [J].

Chen, Minhui ;

Singh, Anurag K. ;

Repasky, Elizabeth A. .

CANCERS, 2020, 12 (12) :1-32

[2] Adrenergic stress constrains the development of anti-tumor immunity and abscopal responses following local radiation [J].

Chen, Minhui ;

Qiao, Guanxi ;

Hylander, Bonnie L. ;

Mohammadpour, Hemn ;

Wang, Xiang-Yang ;

Subjeck, John R. ;

Singh, Anurag K. ;

Repasky, Elizabeth A. .

NATURE COMMUNICATIONS, 2020, 11 (01)

[3] Concurrent β-blocker Use is Associated With Improved Outcome in Esophageal Cancer Patients Who Undergo Chemoradiation A Retrospective Matched-pair Analysis [J].

Farrugia, Mark K. ;

Ma, Sung Jun ;

Mattson, David M. ;

Flaherty, Leayn ;

Repasky, Elizabeth A. ;

Singh, Anurag K. .

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2020, 43 (12) :889-894

[4] Phase I Clinical Trial of Combination Propranolol and Pembrolizumab in Locally Advanced and Metastatic Melanoma: Safety, Tolerability, and Preliminary Evidence of Antitumor Activity [J].

Gandhi, Shipra ;

Pandey, Manu R. ;

Attwood, Kristopher ;

Ji, Wenyan ;

Witkiewicz, Agnieszka K. ;

Knudsen, Erik S. ;

Allen, Cheryl ;

Tario, Joseph D. ;

Wallace, Paul K. ;

Cedeno, Carlos D. ;

Levis, Maria ;

Stack, Suzanne ;

Funchain, Pauline ;

Drabick, Joseph J. ;

Bucsek, Mark J. ;

Puzanov, Igor ;

Mohammadpour, Hemn ;

Repasky, Elizabeth A. ;

Ernstoff, Marc S. .

CLINICAL CANCER RESEARCH, 2021, 27 (01) :87-95

[5] Dopamine and norepinephrine are embracing their immune side and so should we [J].

Gaskill, Peter J. ;

Khoshbouei, Habibeh .

CURRENT OPINION IN NEUROBIOLOGY, 2022, 77

[6] Norepinephrine inhibits CD8+ T-cell infiltration and function, inducing anti-PD-1 mAb resistance in lung adenocarcinoma [J].

Geng, Qishun ;

Li, Lifeng ;

Shen, Zhibo ;

Zheng, Yuanyuan ;

Wang, Longhao ;

Xue, Ruyue ;

Xue, Wenhua ;

Peng, Mengle ;

Zhao, Jie .

BRITISH JOURNAL OF CANCER, 2023, 128 (07) :1223-1235

[7] The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion [J].

Globig, Anna-Maria ;

Zhao, Steven ;

Roginsky, Jessica ;

Maltez, Vivien I. ;

Guiza, Juan ;

Avina-Ochoa, Natalia ;

Heeg, Maximilian ;

Araujo Hoffmann, Filipe ;

Chaudhary, Omkar ;

Wang, Jiawei ;

Senturk, Gokhan ;

Chen, Dan ;

O'Connor, Carolyn ;

Pfaff, Samuel ;

Germain, Ronald N. ;

Schalper, Kurt A. ;

Emu, Brinda ;

Kaech, Susan M. .

NATURE, 2023, 622 (7982) :383-392

[8]

James Caitlin M, 2023, Temperature (Austin), V10, P166, DOI [10.1080/23328940.2022.2093561, 10.1080/23328940.2022.2093561]

[9] Chronic Adrenergic Stress Contributes to Metabolic Dysfunction and an Exhausted Phenotype in T Cells in the Tumor Microenvironment [J].

Qiao, Guanxi ;

Chen, Minhui ;

Mohammadpour, Hemn ;

MacDonald, Cameron R. ;

Bucsek, Mark J. ;

Hylander, Bonnie L. ;

Barbi, Joseph J. ;

Repasky, Elizabeth A. .

CANCER IMMUNOLOGY RESEARCH, 2021, 9 (06) :651-664

[10] Optogenetic activation of local colonic sympathetic innervations attenuates colitis by limiting immune cell extravasation [J].

Schiller, Maya ;

Azulay-Debby, Hilla ;

Boshnak, Nadia ;

Elyahu, Yehezqel ;

Korin, Ben ;

Ben-Shaanan, Tamar L. ;

Koren, Tamar ;

Krot, Maria ;

Hakim, Fahed ;

Rolls, Asya .

IMMUNITY, 2021, 54 (05) :1022-+

← 1 →