Tumour microenvironment characterisation to stratify patients for hyperthermic intraperitoneal chemotherapy in high-grade serous ovarian cancer (OVHIPEC-1)

被引：0

作者：

Aronson, S. Lot ^{[1
,2
]}

Walker, Cedric ^{[3
,4
]}

Thijssen, Bram ^{[5
,6
]}

van de Vijver, Koen K. ^{[1
,7
,8
]}

Horlings, Hugo M. ^{[9
]}

Sanders, Joyce ^{[9
]}

Alkemade, Maartje ^{[10
]}

Koole, Simone N. ^{[1
]}

Lopez-Yurda, Marta ^{[11
]}

Lok, Christianne A. R. ^{[1
]}

van Driel, W. J. ^{[1
]}

Hermans, H. M. ^{[14
]}

van Leeuwen, J. H. Schagen

Schreuder, H. W. R.

van Gent, M. D. J. M.

van Ham, M. A. P. C.

Arts, H. J. G.

van Dam, P. A.

Vuylsteke, P.

Rottenberg, Sven ^{[3
,12
]}

van Rheenen, Jacco ^{[13
]}

Sonke, Gabe S. ^{[2
]}

van Driel, Willemien J. ^{[1
]}

Kester, Lennart A. ^{[14
]}

Hahn, Kerstin ^{[13
,14
]}

机构：

[1] Netherlands Canc Inst, Ctr Gynecol Oncol Amsterdam, Dept Gynecol Oncol, Amsterdam, Netherlands

[2] Netherlands Canc Inst, Dept Med Oncol, Amsterdam, Netherlands

[3] Univ Bern, Inst Anim Pathol, Vetsuisse Fac, Bern, Switzerland

[4] Univ Bern, Grad Sch Cellular & Biomed Sci, Bern, Switzerland

[5] Netherlands Canc Inst, Oncode Inst, Div Mol Carcinogenesis, Amsterdam, Netherlands

[6] Oncode Inst, Utrecht, Netherlands

[7] Ghent Univ Hosp, Dept Pathol, Ghent, Belgium

[8] Ghent Univ Hosp, Canc Res Inst Ghent CRIG, Ghent, Belgium

[9] Netherlands Canc Inst, Dept Pathol, Amsterdam, Netherlands

[10] Netherlands Canc Inst, Core Facil Mol Pathol & Biobanking, Amsterdam, Netherlands

[11] Netherlands Canc Inst, Dept Biometr, Amsterdam, Netherlands

[12] Univ Bern, Bern Ctr Precis Med, Bern, Switzerland

[13] Netherlands Canc Inst, Oncode Inst, Dept Mol Pathol, Amsterdam, Netherlands

[14] Princess Maxima Ctr Pediat Oncol, Utrecht, Netherlands

来源：

BRITISH JOURNAL OF CANCER | 2024年 / 131卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

INFILTRATING IMMUNE CELLS; PROGRESSION; SURVIVAL;

D O I：

10.1038/s41416-024-02731-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundHyperthermic intraperitoneal chemotherapy (HIPEC) improves survival in patients with Stage III ovarian cancer following interval cytoreductive surgery (CRS). Optimising patient selection is essential to maximise treatment efficacy and avoid overtreatment. This study aimed to identify biomarkers that predict HIPEC benefit by analysing gene signatures and cellular composition of tumours from participants in the OVHIPEC-1 trial.MethodsWhole-transcriptome RNA sequencing data were retrieved from high-grade serous ovarian cancer (HGSOC) samples from 147 patients obtained during interval CRS. We performed differential gene expression analysis and applied deconvolution methods to estimate cell-type proportions in bulk mRNA data, validated by histological assessment. We tested the interaction between treatment and potential predictors on progression-free survival using Cox proportional hazards models.ResultsWhile differential gene expression analysis did not yield any predictive biomarkers, the cellular composition, as characterised by deconvolution, indicated that the absence of macrophages and the presence of B cells in the tumour microenvironment are potential predictors of HIPEC benefit. The histological assessment confirmed the predictive value of macrophage absence.ConclusionImmune cell composition, in particular macrophages absence, may predict response to HIPEC in HGSOC and these hypothesis-generating findings warrant further investigation.Clinical trial registrationNCT00426257.

引用

页码：565 / 576

页数：12

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