Anti-Atherosclerotic Properties of Aronia melanocarpa Extracts Influenced by Their Chemical Composition Associated with the Ripening Stage of the Berries

被引：4

作者：

Zielinska, Agnieszka ^{[1
]}

Bryk, Dorota ^{[2
]}

Paradowska, Katarzyna ^{[1
]}

Siudem, Pawel ^{[1
]}

Wawer, Iwona ^{[3
]}

Wrzosek, Malgorzata ^{[2
,4
]}

机构：

[1] Med Univ Warsaw, Fac Pharm, Dept Organ & Phys Chem, Banacha 1, PL-02097 Warsaw, Poland

[2] Med Univ Warsaw, Fac Pharm, Dept Biochem & Pharmacogen, Banacha 1, PL-02097 Warsaw, Poland

[3] State Univ Appl Sci, Dept Herbol, Rynek 1, PL-38400 Krosno, Poland

[4] Med Univ Warsaw, Ctr Preclin Res, Banacha 1B, PL-02097 Warsaw, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 08期

关键词：

Aronia melanocarpa; anthocyanins; chlorogenic acids; inflammation; adhesion molecules; endothelial cells; BLOOD-PRESSURE; CHLOROGENIC ACID; CHOKEBERRY; ANTIOXIDANT; INFLAMMATION; VCAM-1; ATHEROSCLEROSIS; ANTHOCYANINS; ICAM-1; JUICE;

D O I：

10.3390/ijms25084145

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The high content of bioactive compounds in Aronia melanocarpa fruit offers health benefits. In this study, the anti-atherosclerotic effect of Aronia extracts was assessed. The impact on the level of adhesion molecules and the inflammatory response of human umbilical vein endothelial cells (HUVECs) was shown in relation to the chemical composition and the stage of ripening of the fruits. Samples were collected between May (green, unripe) and October (red, overripe) on two farms in Poland, which differed in climate. The content of chlorogenic acids, anthocyanins, and carbohydrates in the extracts was determined using HPLC-DAD/RI. The surface expression of ICAM-1 and VCAM-1 in HUVECs was determined by flow cytometry. The mRNA levels of VCAM-1, ICAM-1, IL-6, and MCP-1 were assessed using the quantitative real-time PCR method. The farms' geographical location was associated with the quantity of active compounds in berries and their anti-atherosclerotic properties. Confirmed activity for green fruits was linked to their high chlorogenic acid content.

引用

页数：14

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