Sex-specific associations of adolescent motherhood with cognitive function, behavioral problems, and autistic-like traits in offspring and the mediating roles of family conflict and altered brain structure

被引：0

作者：

Ren, Tai ^{[1
,2
]}

Zhang, Lingli ^{[1
,2
]}

Liu, Yongjie ^{[1
,2
]}

Zhang, Qingli ^{[1
,2
]}

Sun, Yunjun ^{[1
,2
]}

Zhou, Wei ^{[1
,2
]}

Huang, Like ^{[1
,2
]}

Wang, Ming ^{[1
,2
]}

Pu, Yiwei ^{[1
,2
]}

Huang, Runqi ^{[1
,2
]}

Chen, Jingyu ^{[1
,2
]}

He, Hua ^{[1
,2
]}

Zhu, Tailin ^{[1
,2
]}

Wang, Susu ^{[1
,2
]}

Chen, Weiran ^{[1
,2
]}

Zhang, Qianlong ^{[1
,2
]}

Du, Wenchong ^{[3
]}

Luo, Qiang ^{[4
]}

Li, Fei ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Shanghai Key Lab Childrens Environm Hlth,Minist Ed, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China

[2] Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Dept Dev & Behav Paediat & Child Primary Care, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China

[3] Nottingham Trent Univ, Sch Social Sci, NTU Psychol, 50 Shakespeare St, Nottingham NG1 4FQ, England

[4] Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Key Lab Computat Neurosci & Brain Inspired Intelli, Minist Educ, 220 Handan Rd, Shanghai 200433, Peoples R China

来源：

BMC MEDICINE | 2024年 / 22卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Adolescent pregnancy; Neurodevelopment; Family environment; Sex difference; Brain structure; PARENTAL AGE; RISK-FACTORS; CHILDHOOD; OUTCOMES; DEPRESSION; SYMPTOMS; ABILITY;

D O I：

10.1186/s12916-024-03442-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Previous studies have linked adolescent motherhood to adverse neurodevelopmental outcomes in offspring, yet the sex-specific effect and underlying mechanisms remain unclear. Methods This study included 6952 children aged 9-11 from the Adolescent Brain Cognitive Development study. The exposed group consisted of children of mothers < 20 years at the time of birth, while the unexposed group was composed of children of mothers aged 20-35 at birth. We employed a generalized linear mixed model to investigate the associations of adolescent motherhood with cognitive, behavioral, and autistic-like traits in offspring. We applied an inverse-probability-weighted marginal structural model to examine the potential mediating factors including adverse perinatal outcomes, family conflict, and brain structure alterations. Results Our results revealed that children of adolescent mothers had significantly lower cognitive scores (beta, - 2.11, 95% CI, - 2.90 to - 1.31), increased externalizing problems in male offspring (mean ratio, 1.28, 95% CI, 1.08 to 1.52), and elevated internalizing problems (mean ratio, 1.14, 95% CI, 0.99 to 1.33) and autistic-like traits (mean ratio, 1.22, 95% CI, 1.01 to 1.47) in female. A stressful family environment mediated similar to 70% of the association with internalizing problems in females, similar to 30% with autistic-like traits in females, and similar to 20% with externalizing problems in males. Despite observable brain morphometric changes related to adolescent motherhood, these did not act as mediating factors in our analysis, after adjusting for family environment. No elevated rate of adverse perinatal outcomes was observed in the offspring of adolescent mothers in this study. Conclusions Our results reveal distinct sex-specific neurodevelopmental outcomes impacts of being born to adolescent mothers, with a substantial mediating effect of family environment on behavioral outcomes. These findings highlight the importance of developing sex-tailored interventions and support the hypothesis that family environment significantly impacts the neurodevelopmental consequences of adolescent motherhood.

引用

页数：13