—An elliptical shape multi-band microstrip patch antenna with narrow semicircle cuts and bulges on two horizontal ends is proposed for Global Positioning System (GPS), Indian Regional Navigation Satellite System (IRNSS), Sub-6 GHz 5G and Wireless Local-Area Network (WLAN) wireless communication applications. The proposed antenna operates at 1.56 GHz, 2.49 GHz, 3.5 GHz, and 5.24 GHz for desired applications, respectively. The proposed antenna, fed by coaxial feeding mounted on Rogers AD255C substrate, has optimized physical dimensions of 80 ×80 ×3.175 mm3 . The semicircle cuts and bulges on horizontal ends on the elliptical element contribute to exciting higher-order modes and affect the current distribution at the resonant frequencies resulting in producing multi-band operations. The proposed antenna is fabricated and tested. The measured return loss characteristic (S11) below −10 dB is −15.2 dB, −19 dB, −22.3 dB, & −27.9 dB, with the radiation efficiency of 58.7%, 94.8%, 93.2%, & 84.9% and peak gain of 3.49 dBi, 6.49 dBi, 4.93 dBi, & 4.46 dBi for desired application band, respectively. The proposed antenna also offers impedance bandwidths of 40 MHz (1.55–1.59 GHz), 90 MHz (2.43–2.52 GHz), 100 MHz (3.44–3.54 GHz), & 90 MHz (5.23–5.32 GHz) at resonant frequencies and relatively stable radiation patterns. Simulated and measured results for the proposed antenna exhibit good agreement. The proposed multi-band antenna offers a simple design and improved performance. © 2023, Electromagnetics Academy. All rights reserved.