In order to allow decision makers to quickly learn from historical cases and make satisfactory emergency decisions, this paper proposes an intelligent approach to the generation of similar emergency cases for landslide disasters based on case reasoning. First, the chromosomal structure is used to construct a gene bank of landslide disaster information. Second, because landslide disaster indicators involve different fields such as geology, meteorology, and the human economy, decision makers have a strong subjective dependence on data understanding. Involving issues in different fields, the landslide hazard indicators are numerically distributed in intervals, and all indicators are screened using pruning. Finally, comprehensive similarities are calculated to obtain similar cases for reference. This paper takes Zigui county landslide in Hubei province as an example to verify the effectiveness of the method, and compares the superiority of this method with other methods. © 2021, Editorial Board of Journal of Systems Engineering Society of China. All right reserved.