Ferroptotic stress drives liver aging and metabolic dysfunction

被引：1
|
作者：
Du, Kuo [1 ]
Diehl, Anna Mae [1 ]
机构：
[1] Duke Univ, Durham, NC 27708 USA
来源：
NATURE AGING | 2024年 / 4卷 / 08期
关键词：
D O I：
10.1038/s43587-024-00654-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Older age is associated with metabolic stress and increases the risk of degeneration of organs that maintain metabolic homeostasis, including the liver. We discovered that aging promotes ferroptosis in hepatocytes, that ferroptotic stress is generally increased in degenerating organs, and that reducing ferroptosis reverses aging-related metabolic dysfunction and liver damage.
引用
收藏
页码：911 / 912
页数：2
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