Identification of a new HIV-1 circulating recombinant form (CRF159_01103) derived from CRF103_01B and CRF01_AE in Hebei Province, China

被引：5
作者：
Fan, Weiguang [1 ]
Zhang, Zhen [2 ]
Shi, Haoxi [1 ]
Jia, Jianru [2 ]
Shi, Penghui [1 ]
Chen, Sisi [1 ]
Lu, Xinli [3 ]
机构：
[1] Peoples Hosp Baoding, Clin Lab, Baoding 071000, Hebei, Peoples R China
[2] Peoples Hosp Baoding, Infect Div, Baoding 071000, Hebei, Peoples R China
[3] Hebei Prov Ctr Dis Control & Prevent, Dept AIDS Res, Shijiazhuang 050021, Hebei, Peoples R China
来源：
SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期
关键词：
HIV-1; Circulating recombinant forms; CRF159_01103; Hebei;
D O I：
10.1038/s41598-024-64156-8
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Recombinant HIV-1 genomes identified in three or more epidemiological unrelated individuals are defined as circulating recombinant forms (CRFs). CRFs can further recombine with other pure subtypes or recombinants to produce secondary recombinants. In this study, a new HIV-1 intersubtype CRF, designated CRF159_01103, isolated from three men who have sex with men with no epidemiological linkage, was identified in Baoding city, Hebei Province, China. CRF159_01103 was derived from CRF103_01B and CRF01_AE. Bayesian molecular clock analysis was performed on the CRF01-AE and CRF103_01B regions of CRF159_01103. The time of origin of CRF159_01103 was predicted to be 2018-2019, indicating that it is a recent recombinant virus. The emergence of CRF159_01103 has increased the complexity of the HIV-1 epidemic in Hebei Province.
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页数：5
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