Ferroptosis: A double-edged sword

被引：25

作者：

Wang, Shengmei ^{[1
]}

Guo, Qiuyan ^{[1
]}

Zhou, Lili ^{[1
]}

Xia, Xinhua ^{[1
]}

机构：

[1] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Hunan, Peoples R China

来源：

CELL DEATH DISCOVERY | 2024年 / 10卷 / 01期

关键词：

X(C)(-) CYSTINE/GLUTAMATE ANTIPORTER; CELL-DEATH; ALPHA-SYNUCLEIN; TUMOR SUPPRESSION; ISCHEMIC-STROKE; CANCER-THERAPY; RAT MODEL; IRON; PROTECTS; MECHANISM;

D O I：

10.1038/s41420-024-02037-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ferroptosis represents a form of programmed cell death that is propelled by iron-dependent lipid peroxidation, thereby being distinguished by the prominent features of iron accumulation and lipid peroxidation. Ferroptosis has been implicated in numerous physiological and pathological phenomena, with mounting indications that it holds significant implications for cancer and other medical conditions. On one side, it demonstrates anti-cancer properties by triggering ferroptosis within malignant cells, and on the other hand, it damages normal cells causing other diseases. Therefore, in this paper, we propose to review the paradoxical regulation of ferroptosis in tumors and other diseases. First, we introduce the development history, concept and mechanism of ferroptosis. The second part focuses on the methods of inducing ferroptosis in tumors. The third section emphasizes the utilization of ferroptosis in different medical conditions and strategies to inhibit ferroptosis. The fourth part elucidates the key contradictions in the control of ferroptosis. Finally, potential research avenues in associated domains are suggested.

引用

页数：16

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