Association Between Aortic Valve Sclerosis and Clonal Hematopoiesis of Indeterminate Potential

被引：6

作者：

Kim, Minkwan ^{[1
,2
]}

Kim, Jin Ju ^{[3
]}

Lee, Seung-Tae ^{[4
]}

Shim, Yeeun ^{[5
]}

Lee, Hyeonah ^{[5
]}

Bae, Sunga ^{[1
]}

Son, Nak-Hoon ^{[6
]}

Shin, Saeam ^{[4
,7
]}

Jung, In Hyun ^{[2
,8
,9
]}

机构：

[1] Yonsei Univ, Yongin Severance Hosp, Dept Internal Med, Div Cardiol,Coll Med, Yongin, South Korea

[2] Cardiovasc Ctr, Yongin, South Korea

[3] Yonsei Univ, Coll Med, Yongin Severance Hosp, Dept Lab Med, Yongin, South Korea

[4] Yonsei Univ, Severance Hosp, Dept Lab Med, Coll Med, Seoul, South Korea

[5] Yonsei Univ, Dept Lab Med, Grad Sch Med Sci, Brain Korea 21 PLUS Project,Coll Med, Seoul, South Korea

[6] Keimyung Univ, Dept Stat, Taegu, South Korea

[7] Yonsei Univ, Coll Med, Severance Hosp, Dept Lab Med, 50 Yonsei Ro, Seoul 03722, South Korea

[8] Yonsei Univ, Coll Med, Dept Internal Med, Yongin Severance Hosp,Div Cardiol, 363 Dongbaekjukjeon Daero, Yongin 16995, South Korea

[9] Cardiovasc Ctr, 363 Dongbaekjukjeon Daero, Yongin 16995, South Korea

来源：

ANNALS OF LABORATORY MEDICINE | 2024年 / 44卷 / 03期

关键词：

Aortic valve sclerosis; Clonal hematopoiesis; High-throughput nucleotide sequencing; Inflammation; Variant allele frequency; AMERICAN-SOCIETY; ATHEROSCLEROSIS; CALCIFICATION; DISEASE; DRIVER; ECHOCARDIOGRAPHY; QUANTIFICATION; INFLAMMATION; CORONARY; FAILURE;

D O I：

10.3343/alm.2023.0268

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: The mechanism and medical treatment target for degenerative aortic valve disease, including aortic stenosis, is not well studied. In this study, we investigated the effect of clonal hematopoiesis of indeterminate potential (CHIP) on the development of aortic valve sclerosis (AVS), a calcified aortic valve without significant stenosis. Methods: Participants with AVS (valves >= 2 mm thick, high echogenicity, and a peak transaortic velocity of <2.5 m/sec) and an age- and sex-matched control group were enrolled. Twenty-four CHIP genes with common variants in cardiovascular disease were used to generate a next-generation sequencing panel. The primary endpoint was the CHIP detection rate between the AVS and control groups. Inverse-probability treatment weighting (IPTW) analysis was performed to adjust for differences in baseline characteristics. Results: From April 2020 to April 2022, 187 participants (125 with AVS and 62 controls) were enrolled; the mean age was 72.6 +/- 8.5 yrs, and 54.5% were male. An average of 1.3 CHIP variants was observed. CHIP detection, defined by a variant allele frequency (VAF) of >= 0.5%, was similar between the groups. However, the AVS group had larger CHIP clones: 49 (39.2%) participants had a VAF of >= 1% (vs. 13 [21.0%] in the control group; P = 0.020), and 25 (20.0%) had a VAF of >= 2% (vs. 4 [6.5%]; P = 0.028). AVS is independently associated with a VAF of >= 1% (adjusted odds ratio: 2.44, 95% confidence interval: 1.11-5.36; P = 0.027). This trend was concordant and clearer in the IPTW cohort. Conclusions: Participants with AVS more commonly had larger CHIP clones than age- and sex-matched controls. Further studies are warranted to identify causality between AVS and CHIP.

引用

页码：279 / 288

页数：10

共 40 条

[1] Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure [J].