Untargeted Metabolomic Profiling of Fructus Chebulae and Fructus Terminaliae Billericae

被引：1

作者：

Song, Yuman ^{[1
]}

Gong, Hede ^{[1
]}

机构：

[1] Southwest Forestry Univ, Coll Geog & Ecotourism, Kunming 650224, Peoples R China

来源：

APPLIED SCIENCES-BASEL | 2024年 / 14卷 / 07期

关键词：

Fructus Chebulae; Fructus Terminaliae Billericae; metabolomics; differential metabolites; KEGG analysis; RETZ; EXTRACT; ACID;

D O I：

10.3390/app14073123

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This study aims to identify the differences in metabolites between Fructus Chebulae (FC) and Fructus Terminaliae Billericae (FTB). Untargeted metabolomics was used to analyze differentially expressed metabolites (DEMs) with ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS). A grand total of 558 metabolites were detected, with 155 in positive ion mode and 403 in negative ion mode. Further differential analysis yielded 110 and 87 significantly different metabolites, which were mainly polyphenols, flavonoids, terpenoids, and alkaloids. Analysis of KEGG data showed that differentially expressed metabolites (DEMs) in both positive and negative ion modes were found to be enriched in 5 and 18 metabolic pathways, respectively, with metabolic pathways being the most enriched among them. In sum, this study reveals the differential metabolic profiles of FC and FTB and provides support for their further applications in traditional Chinese medicine.

引用

页数：16

共 34 条

[1] Isolation, Identification and Pharmacological Effects of Mandragora autumnalis Fruit Flavonoids Fraction [J].

Al-Maharik, Nawaf ;

Jaradat, Nidal ;

Bassalat, Najlaa ;

Hawash, Mohammed ;

Zaid, Hilal .

MOLECULES, 2022, 27 (03)

[2] Understanding phenolic acids inhibition of α-amylase and α-glucosidase and influence of reaction conditions [J].

Aleixandre, Andrea ;

Vicente Gil, Jose ;

Sineiro, Jorge ;

Rosell, Cristina M. .

FOOD CHEMISTRY, 2022, 372

[3] Lipid bilayer properties potentially contributed to the evolutionary disappearance of betaine lipids in seed plants [J].

Bolik, Stephanie ;

Schlaich, Alexander ;

Mukhina, Tetiana ;

Amato, Alberto ;

Bastien, Olivier ;

Schneck, Emanuel ;

Deme, Bruno ;

Jouhet, Juliette .

BMC BIOLOGY, 2023, 21 (01)

[4]

Cui Hong-xia, 2015, Yaoxue Xuebao, V50, P45

[5]

Cui W., 2022, Bot. Med, V1, P1, DOI [10.13718/j.cnki.zwyx.2022.06.001, DOI 10.13718/J.CNKI.ZWYX.2022.06.001]

[6]

Dai M., 2021, Zhongnan Pharm, V19, P909

[7] Repeated oral dose toxicity study on hydrolysable tannin rich fraction isolated from fruit pericarps of Terminalia chebula Retz in Wistar albino rats [J].

Ekambaram, Sanmuga Priya ;

Babu, Keerthi B. ;

Perumal, Senthamil Selvan ;

Rajendran, Durgalakshmi .

REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2018, 92 :182-188

[8] Biotransformation of Liquiritigenin into Characteristic Metabolites by the Gut Microbiota [J].

Keranmu, Adili ;

Pan, Li-Bin ;

Fu, Jie ;

Han, Pei ;

Yu, Hang ;

Zhang, Zheng-Wei ;

Xu, Hui ;

Yang, Xin-Yu ;

Hu, Jia-Chun ;

Zhang, Hao-Jian ;

Bu, Meng-Meng ;

Jiang, Jian-Dong ;

Xing, Nian-Zeng ;

Wang, Yan .

MOLECULES, 2022, 27 (10)

[9]

Kolde R., 2015, R PACKAGE VERSION 06

[10] Isolation of chebulic acid from Terminalia chebula Retz. and its antioxidant effect in isolated rat hepatocytes [J].

Lee, Hyun-Sun ;

Jung, Sung-Hoon ;

Yun, Bong-Sik ;

Lee, Kwang-Won .

ARCHIVES OF TOXICOLOGY, 2007, 81 (03) :211-218

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