Prognostic value of neutrophil-to-lymphocyte ratio (NLR) and platelet-neutrophil (PN) index in locally advanced rectal cancer patients: a retrospective cohort study

被引：1

作者：

Morais, Marina ^{[1
,5
]}

Fonseca, Telma ^{[3
]}

Machado-Neves, Raquel ^{[2
]}

Honavar, Mrinalini ^{[2
]}

Coelho, Ana Rita ^{[4
]}

Lopes, Joanne ^{[4
]}

Guerreiro, Emanuel ^{[1
]}

Carneiro, Silvestre ^{[3
]}

机构：

[1] Unidade Local Saude Matosinhos, Dept Surg, Senhora Da Hora, Portugal

[2] Unidade Local Saude Matosinhos, Dept Pathol Anat, Senhora Da Hora, Portugal

[3] Ctr Hosp Univ Sao Joao, Dept Surg, Porto, Italy

[4] Ctr Hosp Univ Sao Joao, Dept Pathol Anat, Porto, Portugal

[5] Hosp Pedro Hispano, Rua Dr Eduardo Torres, P-4464513 Senhora De Hora, Portugal

来源：

ANNALS OF MEDICINE AND SURGERY | 2024年 / 86卷 / 05期

关键词：

neoadjuvant chemoradiotherapy; neutrophil-to-lymphocyte ratio; pathological response; personalized medicine; platelet-neutrophil index; platelet-to-lymphocyte ratio; prognosis; rectal cancer; TOTAL MESORECTAL EXCISION; COLORECTAL-CANCER; PREOPERATIVE CHEMORADIOTHERAPY; NEOADJUVANT CHEMORADIOTHERAPY; PREDICTING PROGNOSIS; OPEN-LABEL; SURVIVAL; OUTCOMES; CHEMOTHERAPY; MULTICENTER;

D O I：

10.1097/MS9.0000000000001297

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction:In locally advanced rectal cancers (LARC), tumour node metastasis (TNM) staging is far from optimal. The authors aimed to investigate the value of previously described circulating biomarkers as predictors of prognosis.Methods:Retrospective analysis of 245 LARC patients diagnosed between January 2010 and December 2022, who underwent neoadjuvant chemoradiotherapy and surgery at two centres. A Cox regression and Kaplan-Meier analysis were performed.Results:Post-treatment platelet-to-lymphocyte ratio (PLR) predicted pathological complete response. The neutrophil-to-lymphocyte ratio (NLR) in two timepoints of the treatment significantly predicted overall survival, whereas the platelet-neutrophil (PN) index significantly predicted disease-free survival. In pathological stage II, the PN index predicted patients with a higher risk of disease-free survival.Conclusion:Blood parameters might allow the definition of subgroups of risk beyond TNM for the application of different therapeutic strategies.

引用

页码：2474 / 2480

页数：7

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