The Thousand Faces of Invasive Group A Streptococcal Infections: Update on Epidemiology, Symptoms, and Therapy

被引：2
作者：
Mercadante, Stefania [1 ]
Ficari, Andrea [2 ]
Romani, Lorenza [1 ]
De Luca, Maia [1 ]
Tripiciano, Costanza [1 ]
Chiurchiu, Sara [1 ]
Calo Carducci, Francesca Ippolita [1 ]
Cursi, Laura [1 ]
Di Giuseppe, Martina [1 ]
Krzysztofiak, Andrzej [1 ]
Bernardi, Stefania [1 ]
Lancella, Laura [1 ]
机构：
[1] IRCCS, Bambino Gesu Childrens Hosp, Infect Dis Unit, I-00165 Rome, Italy
[2] Univ Roma Tor Vergata, Residency Sch Pediat, I-00133 Rome, Italy
来源：
CHILDREN-BASEL | 2024年 / 11卷 / 04期
关键词：
invasive Streptococcus pyogenes infection; beta-lactam antibiotics; children; TOXIC-SHOCK-SYNDROME; INTRAVENOUS IMMUNOGLOBULIN THERAPY; NECROTIZING FASCIITIS; PYOGENES DISEASE; CHILDREN; VACCINE; SURVEILLANCE; IMMUNOGENICITY; PNEUMONIAE; PENICILLIN;
D O I：
10.3390/children11040383
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Invasive infections caused by Streptococcus pyogfenes (iGAS), commonly known as Group A Streptococcus, represent a significant public health concern due to their potential for rapid progression and life-threatening complications. Epidemiologically, invasive GAS infections exhibit a diverse global distribution, affecting individuals of all ages with varying predisposing factors. The pathogenesis of invasive GAS involves an array of virulence factors that contribute to tissue invasion, immune evasion, and systemic dissemination. In pediatrics, in the last few years, an increase in iGAS infections has been reported worldwide becoming a challenging disease to diagnose and treat promptly. This review highlights the current knowledge on pathogenesis, clinical presentations, and therapeutic approaches for iGAS in children.
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页数：13
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