Advances, limitations and perspectives in the use of celecoxib-loaded nanocarriers in therapeutics of cancer

被引:0
作者
Santos, Miguel de Jesus Oliveira [1 ,2 ]
Teles-Souza, Jessica [1 ]
de Araujo-Calumby, Renata Freitas [1 ,3 ]
Copeland Jr, Robert L. [4 ,5 ]
Marcelino, Henrique Rodrigues [2 ,6 ]
Vilas-Boas, Deise Souza [1 ,3 ]
机构
[1] Univ Fed Bahia, Hlth Sci Inst, Dept Biomorfol, Lab Immunopathol & Mol Biol, Salvador Ave Reitor Miguel Calmon,S-N, BR-40110100 Salvador, Ba, Brazil
[2] Univ Fed Bahia, Coll Pharm, Postgrad Program Pharm, BR-40170115 Salvador, Ba, Brazil
[3] Univ Fed Bahia, Inst Hlth Sci, Postgrad Program Immunol, BR-40110100 Salvador, Ba, Brazil
[4] Howard Univ, Coll Med, Dept Pharmacol, Washington, DC 20059 USA
[5] Howard Univ, Canc Ctr, Washington, DC 20059 USA
[6] Univ Fed Bahia, Coll Pharm, Dept Med, BR-40170115 Salvador, Ba, Brazil
关键词
Cancer; COX-2; Celecoxib; Nanocarriers; Nanoparticles; Drug delivery systems; CELL-CYCLE ARREST; CYCLOOXYGENASE-2; INHIBITOR; COX-2; DRUG-DELIVERY; CHEMOPREVENTIVE ACTIVITY; TUMOR MICROENVIRONMENT; PROTAMINE NANOCAPSULES; CO-DELIVERY; NANOPARTICLES; DOXORUBICIN;
D O I
10.1186/s11671-024-04070-0
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Cancer is highlighted as a major global health challenge in the XXI century. The cyclooxygenase-2 (COX-2) enzyme rises as a widespread tumor progression marker. Celecoxib (CXB) is a selective COX-2 inhibitor used in adjuvant cancer therapy, but high concentrations are required in humans. In this sense, the development of nanocarriers has been proposed once they can improve the biopharmaceutical, pharmacokinetic and pharmacological properties of drugs. In this context, this article reviews the progress in the development of CXB-loaded nanocarriers over the past decade and their prospects. Recent advances in the field of CXB-loaded nanocarriers demonstrate the use of complex formulations and the increasing importance of in vivo studies. The types of CXB-loaded nanocarriers that have been developed are heterogeneous and based on polymers and lipids together or separately. It was found that the work on CXB-loaded nanocarriers is carried out using established techniques and raw materials, such as poly (lactic-co-glicolic acid), cholesterol, phospholipids and poly(ethyleneglycol). The main improvements that have been achieved are the use of cell surface ligands, the simultaneous delivery of different synergistic agents, and the presence of materials that can provide imaging properties and other advanced features. The combination of CXB with other anti-inflammatory drugs and/or apoptosis inducers appears to hold effective pharmacological promise. The greatest advance to date from a clinical perspective is the ability of CXB to enhance the cytotoxic effects of established chemotherapeutic agents.
引用
收藏
页数:18
相关论文
共 107 条
[51]   Hyaluronic Acid-Decorated Glycol Chitosan Nanoparticles for pH-Sensitive Controlled Release of Doxorubicin and Celecoxib in Nonsmall Cell Lung Cancer [J].
Lee, Ruda ;
Choi, Yu Jin ;
Jeong, Myeong Seon ;
Park, Yong Il ;
Motoyama, Keiichi ;
Kim, Min Woo ;
Kwon, Seung-Hae ;
Choi, Jung Hoon .
BIOCONJUGATE CHEMISTRY, 2020, 31 (03) :923-932
[52]   The EP4 antagonist, L-161,982, induces apoptosis, cell cycle arrest, and inhibits prostaglandin E2-induced proliferation in oral squamous carcinoma Tca8113 cells [J].
Li, Xiaohui ;
Yang, Bo ;
Han, Guoxu ;
Li, Weizhong .
JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2017, 46 (10) :991-997
[53]   Epidermal growth factor receptor-targeted immunoliposomes for delivery of celecoxib to cancer cells [J].
Limasale, Yanuar Dwi Putra ;
Tezcaner, Aysen ;
Ozen, Can ;
Keskin, Dilek ;
Banerjee, Sreeparna .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2015, 479 (02) :364-373
[54]   Comparison of Survival Benefits of Combined Chemotherapy and Radiotherapy Versus Chemotherapy Alone for Uterine Serous Carcinoma A Meta-analysis [J].
Lin, Yanying ;
Zhou, Jingyi ;
Cheng, Yuan ;
Zhao, Lijun ;
Yang, Yuan ;
Wang, Jianliu .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2017, 27 (01) :93-101
[55]   Redox-Responsive Dual Drug Delivery Nanosystem Suppresses Cancer Repopulation by Abrogating Doxorubicin-Promoted Cancer Stemness, Metastasis, and Drug Resistance [J].
Liu, Jia ;
Chang, Bingcheng ;
Li, Qilin ;
Xu, Luming ;
Liu, Xingxin ;
Wang, Guobin ;
Wang, Zheng ;
Wang, Lin .
ADVANCED SCIENCE, 2019, 6 (07)
[56]   Efficiency of Different Treatment Regimens Combining Anti-tumor and Anti-inflammatory Liposomes for Metastatic Breast Cancer [J].
Liu, Jingxuan ;
Sun, Yuqing ;
Liu, Xiao ;
Yang, Yueying ;
Widjaya, Andy Samuel ;
Long, Zhiguo ;
Jiang, Yanyan .
AAPS PHARMSCITECH, 2020, 21 (07)
[57]   HER2/neu expression correlates with vasculogenic mimicry in invasive breast carcinoma [J].
Liu, Tieju ;
Sun, Baocun ;
Zhao, Xiulan ;
Gu, Qiang ;
Dong, Xueyi ;
Yao, Zhi ;
Zhao, Nan ;
Chi, Jiadong ;
Liu, Ning ;
Sun, Ran ;
Ma, Yuemei .
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2013, 17 (01) :116-122
[58]   Inflammation-Driven Nanohitchhiker Enhances Postoperative Immunotherapy by Alleviating Prostaglandin E2-Mediated Immunosuppression [J].
Liu, Yingke ;
He, Jiao ;
Li, Man ;
Ren, Kebai ;
Zhao, Zhihe .
ACS APPLIED MATERIALS & INTERFACES, 2024, 16 (06) :6879-6893
[59]   Novel mucoadhesive celecoxib-loaded cubosomal sponges: Anticancer potential and regulation of myeloid-derived suppressor cells in oral squamous cell carcinoma [J].
Mabrouk, Aya A. ;
El-Mezayen, Nesrine S. ;
Tadros, Mina I. ;
El-Gazayerly, Omaima N. ;
El-Refaie, Wessam M. .
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2023, 182 :62-80
[60]   Quantum dots in imaging, drug delivery and sensor applications [J].
Matea, Cristian T. ;
Mocan, Teodora ;
Tabaran, Flaviu ;
Pop, Teodora ;
Mosteanu, Ofelia ;
Puia, Cosmin ;
Iancu, Cornel ;
Mocan, Lucian .
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2017, 12 :5421-5431