Preventive effects of hesperidin in an experimental model ofs acute lung inflammation

被引：5

作者：

de Souza, Ana Beatriz Farias ^{[1
,2
]}

de Matos, NataIia Alves ^{[1
,2
]}

Castro, Thalles de Freitas ^{[1
,2
]}

Costa, Guilherme de Paula ^{[3
]}

Talvani, Andre ^{[3
]}

Nagato, Akinori Cardozo ^{[4
]}

de Menezes, Rodrigo Cunha Alvim ^{[2
,5
]}

Bezerra, Frank Silva ^{[1
,2
]}

机构：

[1] Fed Univ Ouro Preto UFOP, Dept Biol Sci, Lab Expt Pathophysiol, BR-35402136 Ouro Preto, MG, Brazil

[2] Fed Univ Ouro Preto UFOP, Ctr Res Biol Sci, BR-35402136 Ouro Preto, MG, Brazil

[3] Fed Univ Ouro Preto UFOP, Inst Exact & Biol Sci, Dept Biol Sci, Lab Immunobiol Inflammat, Ouro Preto, MG, Brazil

[4] Univ Fed Juiz de Fora, Reprod Biol Ctr CRB, Immunopathol Lab & Expt Pathol, Juiz De Fora, MG, Brazil

[5] Fed Univ Ouro Preto UFOP, Dept Biol Sci, Lab Cardiovasc Physiol, Ouro Preto, MG, Brazil

来源：

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY | 2024年 / 323卷

关键词：

Hesperidin; Flavonoids; Mechanical ventilation; Acute lung injury; MECHANICAL VENTILATION; IN-VIVO; INJURY; PULMONARY; BIOAVAILABILITY; PATHOGENESIS; INHIBITION; EXPRESSION; STRATEGIES; CYTOKINES;

D O I：

10.1016/j.resp.2024.104240

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

In this study, we hypothesized that long-term administration of hesperidin can modulate the inflammatory response and oxidative stress in animals submitted to mechanical ventilation (MV). Twenty-five C57BL/6 male mice were divided into 5 groups: control, MV, animals receiving hesperidin in three doses 10, 25 and 50 mg/kg. The animals received the doses of hesperidin for 30 days via orogastric gavage, and at the end of the period the animals were submitted to MV. In animals submitted to MV, increased lymphocyte, neutrophil and monocyte/ macrophage cell counts were observed in the blood and airways. Associated to this, MV promoted an increase in inflammatory cytokine levels such as CCL2, IL-12 and TNF alpha. The daily administration of hesperidin in the three doses prevented the effects caused by MV, which was observed by a lower influx of inflammatory cells into the airways, a reduction in inflammatory markers and less oxidative damage.

引用

页数：10

共 71 条

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