Current Advances of Nanomaterial-Based Oral Drug Delivery for Colorectal Cancer Treatment

被引：15
作者：
Wang, Nuoya [1 ,2 ,3 ]
Chen, Liqing [1 ,2 ]
Huang, Wei [1 ,2 ]
Gao, Zhonggao [1 ,2 ]
Jin, Mingji [1 ,2 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Drug Delivery Technol & Novel Form, Beijing 100050, Peoples R China
[3] Yanbian Univ, Dept Pharm, Yanji 133000, Peoples R China
来源：
NANOMATERIALS | 2024年 / 14卷 / 07期
基金：
中国国家自然科学基金;
关键词：
oral; nano-drug delivery system; oral colon-targeted drug delivery system (OCDDS); colorectal cancer; SOLID LIPID NANOPARTICLES; COLON; SYSTEM; ACID; TUMORIGENESIS; MICROFLORA; EXPRESSION; EFFICIENT; APATINIB; CHITOSAN;
D O I：
10.3390/nano14070557
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Colorectal cancer (CRC) is a common malignant tumor, and traditional treatments include surgical resection and radiotherapy. However, local recurrence, distal metastasis, and intestinal obstruction are significant problems. Oral nano-formulation is a promising treatment strategy for CRC. This study introduces physiological and environmental factors, the main challenges of CRC treatment, and the need for a novel oral colon-targeted drug delivery system (OCDDS). This study reviews the research progress of controlled-release, responsive, magnetic, targeted, and other oral nano-formulations in the direction of CRC treatment, in addition to the advantages of oral colon-targeted nano-formulations and concerns about the oral delivery of related therapeutic agents to inspire related research.
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页数：22
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