Mesenchymal stem cell-derived extracellular vesicles: A novel promising neuroprotective agent for Alzheimer's disease

被引：10
作者：
Chang, Jun [1 ,2 ]
Feng, Zihang [3 ]
Li, Yujiao [1 ,2 ]
Lv, Honglin [4 ]
Liu, Shuzhen [1 ,2 ]
Luo, Yongyin [1 ,2 ]
Hao, Nan [1 ,2 ]
Zhao, Lan [1 ,2 ]
Liu, Jianwei [4 ]
机构：
[1] Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, 88 Chang Ling Rd, Tianjin 300381, Peoples R China
[2] Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu, Tianjin, Peoples R China
[3] Tianjin Univ Tradit Chinese Med, Sch Nursing, Tianjin, Peoples R China
[4] Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China
来源：
BIOCHEMICAL PHARMACOLOGY | 2024年 / 222卷
基金：
中国国家自然科学基金;
关键词：
Mesenchymal stem cell; Extracellular vesicle; Exosome; Neuroprotective; Alzheimer's disease; Amyloid-ss; INFLAMMATORY RESPONSES; EXOSOMES; NEUROGENESIS; DYSFUNCTION; STRESS; RESCUE; DAMAGE; MICE;
D O I：
10.1016/j.bcp.2024.116064
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive loss of neurons in the brain. However, there are no effective drugs for AD. Mesenchymal stem cell-derived extracellular vesicles (MSCsEVs), as a new mediator of intercellular communication, are associated with low immunogenicity, low risk of tumor formation, and good safety profile. Therefore, MSCs-EVs may be a safe and attractive cell-free nanotherapeutics, offering a new perspective for AD treatment. Although preclinical studies have demonstrated that MSCs-EVs have significant neuroprotective effects, the underlying mechanism is unclear. This study aimed to: outline the diagnostic and delivery roles of MSCs-EVs for AD treatment; summarize the optimal sources and delivery methods of MSCs-EVs; provide a comprehensive review on the neuroprotective mechanisms of MSCsEVs; explore how to enhance the neuroprotective effects of MSCs-EVs; and discuss the limitations and potential of their translation to the clinic. Therefore, this study may provide a more precise theoretical reference and practical basis for clinical research of MSCs-EVs.
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页数：20
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