Distinct effects of blood pressure parameters on Alzheimer's and vascular markers in 1,952 Asian individuals without dementia

被引：1

作者：

Lee, Sungjoo ^{[1
]}

Kim, Si Eun ^{[2
,3
]}

Jang, Hyemin ^{[2
,4
]}

Kim, Jun Pyo ^{[2
,5
,6
]}

Sohn, Gyeongmo ^{[3
]}

Park, Yu Hyun ^{[5
,6
]}

Ham, Hongki ^{[5
,6
]}

Gu, Yuna ^{[2
,5
,6
]}

Park, Chae Jung ^{[7
]}

Kim, Hee Jin ^{[2
,5
,6
]}

Na, Duk L. ^{[2
,5
,6
]}

Kim, Kyunga ^{[1
,8
,9
]}

Seo, Sang Won ^{[2
,5
,6
,10
,11
,12
]}

机构：

[1] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol SAIHST, Dept Digital Hlth, 81 Irwon Ro, Seoul 06351, South Korea

[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, 81 Irwon Ro, Seoul 06351, South Korea

[3] Inje Univ, Haeundae Paik Hosp, Dept Neurol, Coll Med, Busan 48108, South Korea

[4] Seoul Natl Univ, Coll Med, Dept Neurol, Seoul Natl Univ Hosp, Seoul 03080, South Korea

[5] Samsung Med Ctr, Neurosci Ctr, Seoul 06351, South Korea

[6] Alzheimers Dis Convergence Res Ctr, Samsung Med Ctr, Seoul 06351, South Korea

[7] Natl Canc Ctr, Res Inst, Goyang 10408, South Korea

[8] Res Inst Future Med, Biomed Stat Ctr, Samsung Med Ctr, 81 Irwon Ro, Seoul 06351, South Korea

[9] Sungkyunkwan Univ, Dept Data Convergence & Future Med, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea

[10] Sungkyunkwan Univ, Dept Hlth Sci & Technol, SAIHST, Seoul 06351, South Korea

[11] Samsung Med Ctr, Ctr Clin Epidemiol, Seoul 06351, South Korea

[12] Sungkyunkwan Univ, Dept Clin Res Design & Evaluat, SAIHST, Seoul 06351, South Korea

来源：

ALZHEIMERS RESEARCH & THERAPY | 2024年 / 16卷 / 01期

关键词：

Blood pressure; Blood pressure variability; Amyloid-beta; Tau; Vascular burden; Hippocampal volume; Cognition; DISEASE; BRAIN; HYPERTENSION; GUIDELINES;

D O I：

10.1186/s13195-024-01483-y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background Risk factors for cardiovascular disease, including elevated blood pressure, are known to increase risk of Alzheimer's disease. There has been increasing awareness of the relationship between long-term blood pressure (BP) patterns and their effects on the brain. We aimed to investigate the association of repeated BP measurements with Alzheimer's and vascular disease markers.Methods We recruited 1,952 participants without dementia between August 2015 and February 2022. During serial clinic visits, we assessed both systolic BP (SBP) and diastolic BP (DBP), and visit-to-visit BP variability (BPV) was quantified from repeated measurements. In order to investigate the relationship of mean SBP (or DBP) with Alzheimer's and vascular markers and cognition, we performed multiple linear and logistic regression analyses after controlling for potential confounders (Model 1). Next, we investigated the relationship of with variation of SBP (or DBP) with the aforementioned variables by adding it into Model 1 (Model 2). In addition, mediation analyses were conducted to determine mediation effects of Alzheimer's and vascular makers on the relationship between BP parameters and cognitive impairment.Results High A beta uptake was associated with greater mean SBP (beta = 1.049, 95% confidence interval 1.016-1.083). High vascular burden was positively associated with mean SBP (odds ratio = 1.293, 95% CI 1.015-1.647) and mean DBP (1.390, 1.098-1.757). High tau uptake was related to greater systolic BPV (0.094, 0.001-0.187) and diastolic BPV (0.096, 0.007-0.184). High A beta uptake partially mediated the relationship between mean SBP and the Mini-Mental State Examination (MMSE) scores. Hippocampal atrophy mediated the relationship between diastolic BPV and MMSE scores.Conclusions Each BP parameter affects Alzheimer's and vascular disease markers differently, which in turn leads to cognitive impairment. Therefore, it is necessary to appropriately control specific BP parameters to prevent the development of dementia. Furthermore, a better understanding of pathways from specific BP parameters to cognitive impairments might enable us to select the managements targeting the specific BP parameters to prevent dementia effectively.

引用

页数：12

共 65 条

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