Immune cells in skin inflammation, wound healing, and skin cancer

被引：7

作者：

Zhang, Yuhan ^{[1
,2
,3
]}

Lu, Qianjin ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Dermatol, Jiangwangmiao St 12, Nanjing 210042, Peoples R China

[2] Chinese Acad Med Sci, Key Lab Basic & Translat Res Immune Mediated Skin, Jiangwangmiao St 12, Nanjing 210042, Peoples R China

[3] Chinese Acad Med Sci & Peking Union Med Coll, Inst Dermatol, Jiangsu Key Lab Mol Biol Skin Dis & STIs, Nanjing 210042, Peoples R China

[4] Chinese Acad Med Sci & Peking Union Med Coll, Inst Dermatol, Nanjing, Peoples R China

[5] Chinese Acad Med Sci, Key Lab Basic & Translat Res Immune Mediated Skin, Nanjing, Peoples R China

[6] Jiangsu Key Lab Mol Biol Skin Dis & STIs, Nanjing, Peoples R China

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2024年 / 115卷 / 05期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

AD; BP; SLE; SSTI; immune cells; inflammation; psoriasis; skin; skin cancer; urticaria; wound healing; DELTA T-CELLS; STAPHYLOCOCCUS-AUREUS SKIN; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ATOPIC-DERMATITIS; MAST-CELLS; NEUTROPHIL RECRUITMENT; DENDRITIC CELLS; TH17; CYTOKINES; HOST-DEFENSE; PIVOTAL ROLE;

D O I：

10.1093/jleuko/qiad107

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Given the self-evident importance of cutaneous immunity in the maintenance of body-surface homeostasis, disturbance of the steady-state skin is inextricably intertwined with dysfunction in cutaneous immunity. It is often overlooked by people that skin, well-known as a solid physical barrier, is also a strong immunological barrier, considering the abundant presence of immune cells including lymphocytes, granulocytes, dendritic cells, and macrophages. What's more, humoral immune components including cytokines, immunoglobulins, and antimicrobial peptides are also rich in the skin. This review centers on skin inflammation (acute and chronic, infection and aseptic inflammation), wound healing, and skin cancer to elucidate the elaborate network of immune cells in skin diseases.

引用

页码：852 / 865

页数：14

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