Immune cells in skin inflammation, wound healing, and skin cancer

被引：7
作者：
Zhang, Yuhan [1 ,2 ,3 ]
Lu, Qianjin [1 ,2 ,3 ,4 ,5 ,6 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Dermatol, Jiangwangmiao St 12, Nanjing 210042, Peoples R China
[2] Chinese Acad Med Sci, Key Lab Basic & Translat Res Immune Mediated Skin, Jiangwangmiao St 12, Nanjing 210042, Peoples R China
[3] Chinese Acad Med Sci & Peking Union Med Coll, Inst Dermatol, Jiangsu Key Lab Mol Biol Skin Dis & STIs, Nanjing 210042, Peoples R China
[4] Chinese Acad Med Sci & Peking Union Med Coll, Inst Dermatol, Nanjing, Peoples R China
[5] Chinese Acad Med Sci, Key Lab Basic & Translat Res Immune Mediated Skin, Nanjing, Peoples R China
[6] Jiangsu Key Lab Mol Biol Skin Dis & STIs, Nanjing, Peoples R China
来源：
JOURNAL OF LEUKOCYTE BIOLOGY | 2024年 / 115卷 / 05期
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
AD; BP; SLE; SSTI; immune cells; inflammation; psoriasis; skin; skin cancer; urticaria; wound healing; DELTA T-CELLS; STAPHYLOCOCCUS-AUREUS SKIN; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ATOPIC-DERMATITIS; MAST-CELLS; NEUTROPHIL RECRUITMENT; DENDRITIC CELLS; TH17; CYTOKINES; HOST-DEFENSE; PIVOTAL ROLE;
D O I：
10.1093/jleuko/qiad107
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Given the self-evident importance of cutaneous immunity in the maintenance of body-surface homeostasis, disturbance of the steady-state skin is inextricably intertwined with dysfunction in cutaneous immunity. It is often overlooked by people that skin, well-known as a solid physical barrier, is also a strong immunological barrier, considering the abundant presence of immune cells including lymphocytes, granulocytes, dendritic cells, and macrophages. What's more, humoral immune components including cytokines, immunoglobulins, and antimicrobial peptides are also rich in the skin. This review centers on skin inflammation (acute and chronic, infection and aseptic inflammation), wound healing, and skin cancer to elucidate the elaborate network of immune cells in skin diseases.
引用
收藏
页码：852 / 865
页数：14
相关论文
共 232 条
[21]   Biological Roles Of Neutrophil-Derived Granule Proteins and Cytokines [J].
Cassatella, Marco Antonio ;
Ostberg, Nataliya K. ;
Tamassia, Nicola ;
Soehnlein, Oliver .
TRENDS IN IMMUNOLOGY, 2019, 40 (07) :648-664
[22]   Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses [J].
Chaudhary, Vidyanath ;
Ah Kioon, Marie Dominique ;
Hwang, Sung-Min ;
Mishra, Bikash ;
Lakin, Kimberly ;
Kirou, Kyriakos A. ;
Zhang-Sun, Jeffrey ;
Wiseman, R. Luke ;
Spiera, Robert F. ;
Crow, Mary K. ;
Gordon, Jessica K. ;
Cubillos-Ruiz, Juan R. ;
Barrat, Franck J. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2022, 219 (11)
[23]   The molecular mechanisms supporting the homeostasis and activation of dendritic epidermal T cell and its role in promoting wound healing [J].
Chen, Cheng ;
Meng, Ziyu ;
Ren, He ;
Zhao, Na ;
Shang, Ruoyu ;
He, Weifeng ;
Hao, Jianlei .
BURNS & TRAUMA, 2021, 9
[24]   Targeting interleukin 4 and interleukin 13: a novel therapeutic approach in bullous pemphigoid [J].
Chen, Fangyuan ;
Wang, Yiman ;
Chen, Xinyi ;
Yang, Nan ;
Li, Li .
ANNALS OF MEDICINE, 2023, 55 (01) :1156-1170
[25]   Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid [J].
Chen, RY ;
Ning, G ;
Zhao, ML ;
Fleming, MG ;
Diaz, LA ;
Werb, Z ;
Liu, Z .
JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (08) :1151-1158
[26]   UBE2L3 Reduces TRIM21 Expression and IL-1f3 Secretion in Epidermal Keratinocytes and Improves Psoriasis-Like Skin [J].
Chen, Xue-Yan ;
Xu, Fan ;
Chen, Jia-Qi ;
Landeck, Lilla ;
Chen, Si-Qi ;
Zhou, Yuan ;
Wang, Zhaoyuan ;
Fu, Ni-Chang ;
Zheng, Min ;
Zhang, Xuzhao ;
Man, Xiao-Yong .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2023, 143 (05) :822-+
[27]   Engineered skin bacteria induce antitumor T cell responses against melanoma [J].
Chen, Y. Erin ;
Bousbaine, Djenet ;
Veinbachs, Alessandra ;
Atabakhsh, Katayoon ;
Dimas, Alex ;
Yu, Victor K. ;
Zhao, Aishan ;
Enright, Nora J. ;
Nagashima, Kazuki ;
Belkaid, Yasmine ;
Fischbach, Michael A. .
SCIENCE, 2023, 380 (6641) :203-210
[28]   Neutrophil-derived IL-1β Is Sufficient for Abscess Formation in Immunity against Staphylococcus aureus in Mice [J].
Cho, John S. ;
Guo, Yi ;
Ramos, Romela Irene ;
Hebroni, Frank ;
Plaisier, Seema B. ;
Xuan, Caiyun ;
Granick, Jennifer L. ;
Matsushima, Hironori ;
Takashima, Akira ;
Iwakura, Yoichiro ;
Cheung, Ambrose L. ;
Cheng, Genhong ;
Lee, Delphine J. ;
Simon, Scott I. ;
Miller, Lloyd S. .
PLOS PATHOGENS, 2012, 8 (11)
[29]   IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice [J].
Cho, John S. ;
Pietras, Eric M. ;
Garcia, Nairy C. ;
Ramos, Romela Irene ;
Farzam, David M. ;
Monroe, Holly R. ;
Magorien, Julie E. ;
Blauvelt, Andrew ;
Kolls, Jay K. ;
Cheung, Ambrose L. ;
Cheng, Genhong ;
Modlin, Robert L. ;
Miller, Lloyd S. .
JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (05) :1762-1773
[30]   Targeting L-type amino acid transporter 1 in innate and adaptive T cells efficiently controls skin inflammation [J].
Cibrian, Danay ;
Castillo-Gonzalez, Raquel ;
Fernandez-Gallego, Nieves ;
de la Fuente, Hortensia ;
Jorge, Inmaculada ;
Laura Saiz, Maria ;
Punzon, Carmen ;
Ramirez-Huesca, Marta ;
Vicente-Manzanares, Miguel ;
Fresno, Manuel ;
Dauden, Esteban ;
Fraga-Fernandez, Javier ;
Vazquez, Jesus ;
Aragones, Julian ;
Sanchez-Madrid, Francisco .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2020, 145 (01) :199-+
12345678910