Research Progress in Preparation of Nanostructured Lipid Carriers and Its Application in Functional Foods

被引：0
|
作者：
Shi F. [1 ]
Yang H. [1 ]
机构：
[1] Yanjing Medical College, Capital Medical University, Beijing
来源：
Science and Technology of Food Industry | 2023年 / 44卷 / 15期
关键词：
application; bioactive substances; delivery system; functional foods; nanostructured lipid carriers; preparation techniques;
D O I：
10.13386/j.issn1002-0306.2022120039
中图分类号：
学科分类号：
摘要：
Nanostructured lipid carriers is a new dosage form in food industry. As a delivery system for functional foods, it has a high drug loading and encapsulation rate, which can effectively increase the bioavailability and stability of fat-soluble bioactive substances, improve the nutritional value and safety of food, and control the release of encapsulating materials, so it has a broad application prospect. In this paper, the classification of structural characteristics (imperfect type, amorphous type and multiple type) and several common preparation methods of nanostructured lipid carriers are reviewed, including the process flow as well as the advantages and drawbacks of hot high-pressure homogenization, cold high-pressure homogenization, solvent emulsification diffusion method, solvent emulsification evaporation method, solvent injection/ solvent displacement method, microemulsion technique, emulsification ultrasonic method, membrane contractor, phase inversion techniques and super critical fluid method. The protection and delivery of nanostructured lipid carriers for essential fatty acids, carotenoids, phytosterols, fat-soluble vitamins, polyphenols and other bioactive substances in functional food field are summarized. The limitations and future research trends of nanostructured lipid carriers delivery system in food industry are summarized and discussed, which would provide a theoretical basis for subsequent research. © Science and Technology of Food Industry. All rights reserved.
引用
收藏
页码：1 / 6
页数：5
相关论文
共 57 条
  • [21] HARSHAD S, VANDANA P., Long chain lipid based tamoxifen NLC. Part I: Preformulation studies, formulation development and physicochemical characterization[J], International Journal of Pharmaceutics, 454, 1, (2013)
  • [22] LIU D F, JIANG S M, SHEN H, Et al., Diclofenac sodium-loaded solid lipid nanoparticles prepared by emulsion/solvent evaporation method[J], Journal of Nanoparticle Research, 13, 6, (2011)
  • [23] OLIVEIRA D, MICHELON M, FIGUEIREDO F G, Et al., βCarotene-loaded nanostructured lipid carriers produced by solvent displacement method, Food Res Int, 90, (2016)
  • [24] JOSHI M, PATRAVALE V., Nanostructured lipid carrier (NLC) based gel of celecoxib[J], International Journal of Pharmaceutics, 346, 1-2, (2008)
  • [25] WANG W X, CHEN L N, HUANG X Y, Et al., Preparation and characterization of minoxidil loaded nanostructured lipid carriers[J], AAPS PharmSciTech, 18, 2, (2017)
  • [26] MA Y Q, XIU W Y, LI C C, Et al., Optimization of preparation process for lycopene-loaded nanostructured lipid carrier by central composite design-response surface methodology, Food Science, 42, 3, (2021)
  • [27] CATHERINE C, ASSMA E, HATEM F., Preparation of solid lipid nanoparticles using a membrane contactor, Journal of Controlled Release, 108, 1, (2005)
  • [28] SUN M, NIE S F, PAN X, Et al., Quercetin-nanostructured lipid carriers: Characteristics and anti-breast cancer activities in vitro, Colloids and Surfaces B:Biointerfaces, 113, (2014)
  • [29] LUDTKE F L, STAHL M A, GRIMALDI R, Et al., High oleic sunflower oil and fully hydrogenated soybean oil nanostructured lipid carriers: Development and characterization, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 654, (2022)
  • [30] DARIUSH M, JASON H W., Omega-3 fatty acids and cardiovascular disease[J], Journal of the American College of Cardiology, 58, 20, (2011)
123456